ReviewStem cells translational medicine2025
Metabolic regulation in the senescence process of stem cells.
Review in Stem cells translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cancer stem cells and drug resistance in cancer: molecular mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Plasticity, signaling, and metabolic rewiring in melanoma persister cells.Communications biology · 2026Review
- Review
- Mechanisms of Inflammation Chronification: Gene and Epigenetic Regulation of Intolerant Response (Trained Immunity).Current medicinal chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundAging is an inevitable and complex biological process characterized by progressive cellular and functional deterioration, leading to increased disease susceptibility and mortality. Stem cells, endowed with unique self-renewal and multipotent differentiation capabilities, play a pivotal role in tissue homeostasis and regenerative processes. However, the aging process triggers stem cell senescence, manifested by diminished proliferative capacity and differentiation potential, ultimately compromising tissue regeneration and contributing to the pathogenesis of various age-related disorders, including neurodegeneration, cardiovascular diseases, and metabolic syndromes. MAIN
findingsMetabolic plasticity serves as a fundamental mechanism enabling stem cells to dynamically adapt their energy requirements during self-renewal and lineage commitment. Emerging evidence indicates that cellular metabolism extends beyond its conventional role in energy production, actively participating in the regulation of stem cell fate decisions. Notably, nutrient-sensitive metabolites constitute a sophisticated metabolism-epigenetic axis that integrates metabolic flux, signaling pathways, and epigenetic modifications to precisely orchestrate cellular behavior. This regulatory axis is indispensable for maintaining tissue homeostasis and facilitating regeneration, thereby positioning metabolic reprogramming as a promising therapeutic strategy for mitigating aging-associated decline.
conclusionsIn conclusion, elucidating the intricate crosstalk between stem cell metabolism and the aging process unveils novel opportunities for developing innovative anti-aging interventions and enhancing tissue repair. Future investigations should focus on the precise manipulation of metabolic pathways to effectively counteract age-related functional deterioration and promote longevity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.