Evidence map›Paper›PMID 40973915›Full record

ArticleJournal of medical ultrasonics (2001)2026

Ultrasound findings suggestive of microscopic extranodal extension in papillary thyroid carcinoma.

Noriko Miyamoto, Mitsuyoshi Hirokawa, Miyoko Higuchi, Maki Oshita, Makoto Kawakami, Hiroyuki Yamaoka, Makoto Fujishima, Akira Miyauchi, Takashi Akamizu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical ultrasonics (2001), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Noriko MiyamotoDepartment of Clinical Laboratory, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan. miyamoto01@kuma-h.or.jp.ORCID http://orcid.org/0009-0002-9218-4187
Mitsuyoshi HirokawaDepartment of Diagnostic Pathology and Cytology, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0000-0001-5558-7142
Miyoko HiguchiDepartment of Diagnostic Pathology and Cytology, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0000-0001-8262-2652
Maki OshitaDepartment of Clinical Laboratory, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0009-0003-8597-2916
Makoto KawakamiMedical Information Management Section, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0009-0005-7149-4516
Hiroyuki YamaokaDepartment of Internal Medicine, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0009-0004-0044-2009
Makoto FujishimaDepartment of Surgery, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0009-0006-4537-9423
Akira MiyauchiDepartment of Surgery, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0000-0003-0041-197X
Takashi AkamizuDepartment of Internal Medicine, Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.ORCID http://orcid.org/0000-0003-4960-8271

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExtranodal extension (ENE) of metastatic carcinoma in patients with papillary thyroid carcinoma (PTC) has been associated with an increased risk of recurrent disease, persistent disease, and disease-specific mortality; however, ultrasound findings suggestive of ENE have not been well established. In this study, we aimed to identify ultrasound findings suggestive of microscopic ENE and validate them histologically.

methodsWe retrospectively examined the ultrasound and histological findings of 21 PTC patients with microscopic ENE and 46 without ENE.

resultsNode matting, irregular shapes, ill-defined jagged border, and perinodal hyperechoic rims were observed in 38.1%, 57.1%, 42.9%, and 57.1% of lymph nodes with ENE, respectively, and the frequencies were significantly higher than those without ENE, with p values less than 0.05, 0.0005, 0.0001, and 0.0001, respectively. The sensitivity and specificity of cases with any one of irregular shapes, ill-defined jagged border, and perinodal hyperechoic rims were 81.0% and 82.6%, respectively. Histologically, node matting, irregular shape, ill-defined jagged border, and a perinodal hyperechoic rim correspond to adhesion between lymph nodes, extensive invasion, minimal invasion, and invasion into adipose tissue, respectively.

conclusionsWe would argue that any irregular shape, ill-defined jagged border, and perinodal hyperechoic rim can be accepted as findings indicative of microscopic ENE.

Indexed as

Extranodal ExtensionThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedCarcinoma, PapillaryFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityUltrasonographyYoung AdultExtranodal extensionLymph-node metastasisNode mattingPapillary thyroid carcinomaUltrasound

Identifiers

PMID40973915
PMCPMC12790489

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.