Evidence map›Paper›PMID 40973879›Full record

ArticleNeuroscience bulletin2026

SHANK3 Deficiency in AgRP Neurons Inhibits Diet-Induced Obesity by Activating p38α.

Shanshan Wu, Yixiao Liang, Yang Xu, Yueping Ge, Jing Wang, Lu Wang, Xinchen Jin, Huidong Zhan, Li Peng, Ling Gao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shanshan WuDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Yixiao LiangDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Yang XuDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Yueping GeDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Jing WangDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Lu WangKey Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Key Laboratory of Endocrinology and Lipid Metabolism; Shandong Institute of Endocrine and Metabolic Diseases, Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Xinchen JinAdvanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Huidong ZhanDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Li PengDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Ling GaoKey Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Key Laboratory of Endocrinology and Lipid Metabolism; Shandong Institute of Endocrine and Metabolic Diseases, Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Jiajun ZhaoKey Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Key Laboratory of Endocrinology and Lipid Metabolism; Shandong Institute of Endocrine and Metabolic Diseases, Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Zhao HeDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China. zhaohe@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with autism often exhibit abnormalities in body weight, but the underlying mechanism remains unclear. SH3 and multiple ankyrin repeat domains protein 3 (SHANK3), a scaffold protein of the postsynaptic density, has been reported to be associated with autism. This study aimed to investigate whether and how SHANK3 influences body weight in the hypothalamic neuronal regulation of energy homeostasis. Adeno-associated viruses 9 (AAV9) carrying CMV-Cre and Agrp-Cre were stereotactically injected to restore SHANK3 expression in the arcuate nucleus (ARC) and agouti-related peptide (AgRP) neurons, respectively. Agrp-Cre mice were injected with AAV9-p38α

Indexed as

Agouti-Related ProteinMitogen-Activated Protein Kinase 14Nerve Tissue ProteinsNeuronsObesityAnimalsArcuate Nucleus of HypothalamusBody WeightDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsAgouti-Related ProteinAgrp protein, mouseMicrofilament ProteinsMitogen-Activated Protein Kinase 14Nerve Tissue ProteinsShank3 protein, mouseAgouti-related peptideAutismBody weightp38αSHANK3

Identifiers

PMID40973879
PMCPMC12789283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.