Evidence map›Paper›PMID 40973873›Full record

ArticleJournal of molecular cell biology2026

The tumor-associated fibroblasts regulate urothelial carcinoma progression.

Yu Xiao, Junfeng Yang, Mengjie Sun, Yongfu Li, Qinyin Liu, Jinjun Leng, Maolin Yang, Jinrui Wang, Hongju Li, Caifeng Yang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yu XiaoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Junfeng YangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Mengjie SunThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Yongfu LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Qinyin LiuFujian Provincial Key Laboratory of Tumor Biotherapy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.
Jinjun LengThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Maolin YangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Jinrui WangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Hongju LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Caifeng YangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Changfen LuoThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Jiahong LiThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Longli KangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Fen HuangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Yanhong YuThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.
Chuanmao ZhangThe Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People's Hospital of Yunnan Province/The Affiliated Hospital Department of Urology, Kunming University of Science and Technology, Kunming 650032, China.

Funding

Kunming Medical University 202301AY070001-052National Natural Science Foundation of China 32130026National Natural Science Foundation of China 92254305National Natural Science Foundation of China U20A20395Science and Technology Plan Projects of Tibet Autonomous Region XZ2024-JR
6 · The paper itself

Abstract

Tumor-associated fibroblasts (CAFs) regulate tumorigenesis, tumor cell proliferation, and metastasis via secreting related regulatory factors; however, the role of CAFs in regulating the development of upper tract urothelial carcinoma (UTUC) remains unclear. Here, by utilizing single-cell RNA sequencing, single-nucleus RNA sequencing, SpaTial enhanced resolution omics-sequencing, and UTUC immunofluorescence chip cohort to construct the first comprehensive microenvironmental atlas of CAFs, we investigated the roles of CAFs in UTUC progression. Through hierarchical clustering and the copy number variation scores of UTUC epithelial cells, we classified tumor epithelial cells into high-malignant, medium-malignant, and low-malignant potential categories. We found pronounced interaction signals between different CAF subclusters and all three types of epithelial cells, among which high-malignant epithelial cells exhibited the most significant communication signals with the myofibroblastic CAFs1 (myCAFs1) and myCAFs2 subclusters, and FN1 and COL1A1 generated by CAFs played critical roles in this process, suggesting that the progression of UTUC may be attributed to the activation of tumor cells by CAFs. Additionally, both myCAFs1 and myCAFs2 simultaneously affect bladder urothelial carcinoma (BUC) prognosis, with the risk model showing good consistency across cohorts. Therefore, this study constructs a multi-omics landscape of UTUC and identifies common prognostic markers shared with BUC.

Indexed as

Cancer-Associated FibroblastsUrinary Bladder NeoplasmsCell Line, TumorCollagen Type ICollagen Type I, alpha 1 ChainDisease ProgressionDNA Copy Number VariationsEpithelial CellsFibronectinsGene Expression Regulation, NeoplasticHumansPrognosisSingle-Cell AnalysisTumor MicroenvironmentUrotheliumCollagen Type ICollagen Type I, alpha 1 ChainFibronectinsFN1 protein, humancancer-associated fibroblastsmulti-omics researchtumor microenvironmentupper tract urothelial carcinoma

Identifiers

PMID40973873
PMCPMC13032880

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.