Mitochondrial ATP synthase 8 single-nucleotide polymorphism affects oxidative stress and survival of mice.

Gesine Reichart, Johannes Mayer, Tursonjan Tokay, Timo Kirschstein, Falko Lange, Rüdiger Köhling

Abstract read

In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Reduced Cerebral Infarct Volume in Young UCP2Cells · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gesine Reichart *Oscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany. gesine.reichart@uni-rostock.de.ORCID 0000-0001-7094-7644

Johannes Mayer *Oscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0003-4331-7465

Tursonjan TokayOscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.

Timo KirschsteinOscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.

Falko LangeOscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0001-8782-5205

Rüdiger KöhlingOscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0003-3330-4898

Funding

Bundesministerium für Bildung und Forschung ROSAge 31P6662

6 · The paper itself

Abstract

Single-nucleotide polymorphisms in mitochondrial DNA (mtDNA) encoded genes of respiratory chain complexes are known to be associated with severe diseases and life-threatening syndromes. In the assembly of the ATP synthase, the enzyme that in the final steps of oxidative phosphorylation generates ATP from ADP and inorganic phosphate, two subunits (ATP6 and ATP8) are mtDNA-encoded. In our study, we investigated the impact of a single-nucleotide polymorphism in MT-ATP8 with respect to memory function in a preclinical model. Here, we have employed two conplastic mouse strains. The mouse strain C57BL/6 J-mt

Indexed as

Mitochondrial Proton-Translocating ATPasesOxidative StressPolymorphism, Single NucleotideAnimalsHippocampusLong-Term PotentiationMaleMiceMice, Inbred C57BLMitochondriaReactive Oxygen SpeciesMitochondrial Proton-Translocating ATPasesReactive Oxygen SpeciesAgeingATP synthaseCognitionConplastic mouse strainsLifespanLong-term potentiationMT-ATP8MtDNA variantsOxidative stressSingle-nucleotide polymorphism

Identifiers

PMID40973849

DOI10.1007/s00424-025-03123-2

PMCPMC12640345

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.