Evidence map›Paper›PMID 40973815›Full record

ArticleBioresources and bioprocessing2025

Systematic engineering to enhance valencene production in Rhodobacter sphaeroides.

Zhizhen Li, Wenhao Li, Xinyu Gao, Wenming Yao, Zhenqian Zhu, Xueyi Luo, Yang Zhang, Jifeng Yuan

Abstract read
In one paragraph

Article in Bioresources and bioprocessing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhizhen Li *State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China.
Wenhao Li *State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China.
Xinyu Gao *State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China.
Wenming YaoState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China.
Zhenqian ZhuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China.
Xueyi LuoState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China.
Yang ZhangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China. y-zhang@xmu.edu.cn.ORCID http://orcid.org/0000-0003-1718-0733
Jifeng YuanState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, 361102, China. jfyuan@xmu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities 20720240120National Key Research and Development Program of the Ministry of Science and Technology 2024YFC3407000National Natural Science Foundation of China 32270087National Natural Science Foundation of China 32400058Natural Science Foundation of Xiamen, China 3502Z202471013
6 · The paper itself

Abstract

Microbial synthesis of (+)-valencene from agricultural wastes such as cornstalk will serve as a sustainable alternative to the traditional plant extraction method. In this study, Rhodobacter sphaeroides strains were engineered for valencene production through a stepwise manner: (1) heterologous expression of Callitropsis nootkatensis valencene synthase (CnVS) in combination with phaB/gdhA/ladH knockouts enabled de novo biosynthesis of valencene from glucose at a titer of 34.21 ± 3.1 mg/L; (2) a quorum-sensing promoter P

Indexed as

Agricultural wasteMetabolic engineeringProcess optimizationRhodobacter sphaeroidesValencene

Identifiers

PMID40973815
PMCPMC12449282

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.