ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Comparative polygenic predispositions of treatment-resistant depression in East Asian and European populations.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Large-scale genetic studies of treatment-resistant depression (TRD) have been performed majority on European ancestry cohorts, potentially missing important population-specific biological insights. Understanding the genetic predisposition for TRD across populations could provide insights for etiologic heterogeneity. Conducting a cohort study of 106,796 unrelated participants using Taiwan Biobank (TWBB), we investigated the association of polygenic score (PGS) with the development of TRD among patients with depression and explore the concordance of the PGS association between East Asian and European populations. Three binary outcomes were defined, including TRD vs. non-major depressive disorder (MDD), treatment responsive MDD (trMDD) vs. non-MDD, and TRD vs. trMDD. Six PGSs belong to personality domains (nervous, worry, guilty feelings, neuroticism, tense, and worry embarrassment) and compulsive PGS were associated with TRD vs. trMDD in TWBB. The pattern of association was consistent across TRD definitions with different dose, duration, and interrupted window for antidepressant treatment. The estimated strength of PGS association in TWBB is consistent with that in All of US (AoU) (meta-analytic R
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