ArticleNature communications2025
Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026Article
- Synaptic transmission in supragranular layers of the human cortex - comparative review of structure, function, and plasticity.Frontiers in synaptic neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dendritic calcium action potentials (APs) enable the main output neurons of the cerebral cortex - pyramidal tract neurons (PTs) - to associate inputs that arrive at different cortical layers. How synaptic inputs evoke calcium APs during in vivo conditions is yet unclear. We combine in vivo recordings in male rats with synaptic input reconstructions, multi-scale modelling and optogenetic manipulations. We find that thalamocortical (TC) synapses, which provide sensory input to cortex, target specifically and most densely the dendritic domain that initiates calcium APs in PTs. Sensory input from thalamus is hence a reliable, but weak source for activating the dendritic calcium domain. Because it is fast and local, this activation enables active dendritic coupling of sensory input with multiple sensory-evoked and ongoing input streams that arrive during and surprisingly before the stimulus. This 'TC coupling' mechanism accounts for the modulation of the first sensory responses that leave the cortex with bursts of APs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.