Evidence map›Paper›PMID 40973726›Full record

ArticleNature communications2025

Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide Y

Anette Kaiser, Juan C Rojas Echeverri, Asat Baischew, Maik Pankonin, Karl D Leitner, Claudio Iacobucci, Davide Sala, Christian Ihling, Ronny Müller, Rok Ferenc and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anette KaiserDepartment of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig, Germany. anette.kaiser@medizin.uni-leipzig.de.ORCID http://orcid.org/0000-0002-5477-201X
Juan C Rojas EcheverriDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany.
Asat BaischewDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany.ORCID http://orcid.org/0000-0002-5675-9724
Maik PankoninInstitute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0009-0004-2295-7513
Karl D LeitnerDepartment of Anesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig, Germany.ORCID http://orcid.org/0009-0008-1709-5161
Claudio IacobucciDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany.
Davide SalaInstitute for Drug Discovery, Medical Faculty, Leipzig University, Leipzig, Germany.
Christian IhlingDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany.
Ronny MüllerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
Rok FerencInstitute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.
Annette G Beck-SickingerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4560-8020
Peter SchmidtInstitute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.
Jens MeilerInstitute for Drug Discovery, Medical Faculty, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0001-8945-193X
Peter W HildebrandInstitute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0003-0063-1104
Andrea SinzDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany. andrea.sinz@pharmazie.uni-halle.de.ORCID http://orcid.org/0000-0003-1521-4899

Funding

Bundesministerium für Wirtschaft und Energie (Federal Ministry for Economic Affairs and Energy) ZIM KK5096401SK0Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/A03Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/A04Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/A07Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/B03Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/C01Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/Z03Deutsche Forschungsgemeinschaft (German Research Foundation) 421152132/SFB1423/Z04Deutsche Forschungsgemeinschaft (German Research Foundation) 449501615/RTG2751/INST 271/404-1 FUGGDeutsche Forschungsgemeinschaft (German Research Foundation) 449501615/RTG2751/INST 271/405-1 FUGG
6 · The paper itself

Abstract

Previous efforts in delineating molecular mechanisms of G protein-coupled receptor (GPCR) activation have focused on transmembrane regions and ligand-receptor contacts of the extracellular loops. The role of the highly flexible N-termini of rhodopsin-like GPCRs have not been well characterized to date. We hypothesize that transient contacts between the peptide ligand and the intrinsically disordered N-terminus (NT) of the neuropeptide Y (NPY) receptor Y

Indexed as

Intrinsically Disordered ProteinsReceptors, Neuropeptide YAnimalsArrestinsHEK293 CellsHumansLigandsMolecular Dynamics SimulationNeuropeptide YProtein BindingProtein ConformationSignal Transductionarrestin3ArrestinsIntrinsically Disordered ProteinsLigandsNeuropeptide Yneuropeptide Y2 receptorReceptors, Neuropeptide Y

Identifiers

PMID40973726
PMCPMC12449476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.