Extending the Branches of Neonatal Neurocritical Care.

Mark A Petersen, Hannah C Glass

Abstract readReview

In one paragraph

Review in Seminars in perinatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Less is more: standardizing preclinical hypothermia to advance neonatal neuroprotection.Pediatric research · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark A PetersenDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA. Electronic address: mark.petersen@ucsf.edu.

Hannah C GlassDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA; Department of Neurology and Weill Institute for Neuroscience, and Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Funding

Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV)R01NS111166 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY, SHELLHAAS, RENEE A. · 2020 to 2023

$4.6M

NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy)R01NS124051 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hannah Cranley Glass · 2022 to 2026

$3.3M

Overcoming the Inhibitory Neurovascular Niche in Preterm Infant Brain InjuryR01NS126498 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARK A PETERSEN · 2023 to 2026

$1.9M

NINDS NIH HHS R01 NS111166NINDS NIH HHS R01 NS124051NINDS NIH HHS R01 NS126498

6 · The paper itself

Abstract

Neonatal Neurocritical Care (NNCC) is transforming neonatal medicine through a brain-centered approach that reflects the complexity and rapid progression of early neurodevelopment. NNCC provides a comprehensive care model built on a foundation of real-time neuromonitoring, advanced neuroimaging, and multidisciplinary collaboration to deliver timely neurological support for newborns at risk of injury. This framework has evolved to bridge the full arc of early brain development, linking fetal evaluation, neonatal management, and post-discharge follow-up into a cohesive continuum. Recent technological advances in bedside monitoring, functional neuroimaging, machine learning, and rapid genomics are shifting NNCC toward a more proactive and personalized model of care. Emerging therapies are also expanding the clinical reach of NNCC, opening new frontiers for early intervention and neurorepair. As the field continues to advance, the central goal of NNCC remains to improve neurodevelopmental outcomes while ensuring widespread access to high-quality, family-centered neurological care. This review outlines the evolving landscape of NNCC and highlights its essential role in guiding brain-focused care from the earliest stages of development through childhood and beyond.

Indexed as

BrainCritical CareIntensive Care, NeonatalNeonatologyHumansInfant, NewbornNeuroimagingArtificial intelligence/ machine learningNeurodevelopmental outcomesNeuroimagingNeuromonitoringNeuroprotectionNeurorepairStem cells

Identifiers

PMID40973562

DOI10.1016/j.semperi.2025.152131

PMCPMC12751367

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.