Evidence map›Paper›PMID 40973500›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)

Medial orbitofrontal cortex activation reduces discrimination for threat in male rats.

Jia-Zhen Shih, Chang-Chih Kuo

Abstract read
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jia-Zhen ShihMaster Program in Biomedical Sciences, School of Medicine, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Chang-Chih KuoMaster Program in Biomedical Sciences, School of Medicine, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan cckou@mail.tcu.edu.tw.ORCID http://orcid.org/0009-0008-9490-3126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognizing threats is crucial for animals to adopt appropriate behaviors. The orbitofrontal cortex (OFC) is essential for emotional regulation and cognitive flexibility. This study investigated the effect of medial OFC (mOFC) manipulation on discrimination ability in male rats in a fear differential conditioning paradigm. The rats were conditioned to two different types of conditioned stimuli (CS

Indexed as

Conditioning, ClassicalDiscrimination, PsychologicalFearPrefrontal CortexAnimalsElectroshockGABA-A Receptor AgonistsMaleMuscimolRatsGABA-A Receptor AgonistsMuscimol

Identifiers

PMID40973500
PMCPMC12543027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.