Evidence map›Paper›PMID 40973488›Full record

ArticleeNeuro2025

Differential Encoding of Odor and Place in the Mouse Piriform and Entorhinal Cortex.

Wilson Mena, Keeley Baker, Alon Rubin, Shaun Kohli, Yun Yoo, Brice Bathellier, Yaniv Ziv, Alexander Fleischmann, Shahab Rezaei-Mazinani

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Odors in space.Frontiers in neural circuits · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Wilson MenaUniversité Paris Cité, Institut Pasteur, Unit of Neural Circuits Dynamics and Decision Making, Paris F-75015, France.
Keeley BakerDepartment of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912.
Alon RubinDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Shaun KohliDepartment of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912.
Yun YooDepartment of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912.
Brice BathellierUniversité Paris Cité, Institut Pasteur, AP-HP, INSERM, CNRS, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Paris F-75012, France.
Yaniv ZivDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Alexander FleischmannDepartment of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912 alexander_fleischmann@brown.edu charles.rezaei@emse.fr.
Shahab Rezaei-MazinaniCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, Université PSL, CNRS, INSERM, Paris 75005, France alexander_fleischmann@brown.edu charles.rezaei@emse.fr.ORCID https://orcid.org/0000-0002-7868-4540

Funding

Odor Memory Traces in the Mouse Olfactory Cortex - SupplementR01DC017437 · NIDCD · BROWN UNIVERSITY · PI FLEISCHMANN, ALEXANDER · 2019 to 2023
$2.3M
Advancing the Research Careers of Women and PEERs in Brain ScienceR25NS124530 · NINDS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Diane Lipscombe · 2022 to 2026
$1.3M
NIDCD NIH HHS R01 DC017437NINDS NIH HHS R25 NS124530
6 · The paper itself

Abstract

The integration of olfactory and spatial information is critical for guiding animal behavior. The lateral entorhinal cortex (LEC) is reciprocally interconnected with cortical areas for olfaction and the hippocampus and thus ideally positioned to encode odor-place associations. Here, we used miniendoscopes to record neural activity in the mouse piriform cortex (PCx) and LEC. We show that in head-fixed mice, odor identity could be decoded from LEC ensembles but less accurately than from PCx. In male mice freely navigating a linear track, LEC ensemble activity at the odor ports was dominated by spatial information. Spatial position along the linear track could be decoded from LEC and PCx activity; however, PCx but not LEC exhibited strong behavior-driven modulation of positional information. Together, our data reveal that information about odor cues and spatial context is differentially encoded along the PCx-LEC axis.

Indexed as

Entorhinal CortexNeuronsOdorantsOlfactory PerceptionPiriform CortexSmellSpace PerceptionAction PotentialsAnimalsMaleMiceMice, Inbred C57BLlateral entorhinal cortexnavigationodor encodingpirifrom cortexplace encodingspatial information

Identifiers

PMID40973488
PMCPMC12507510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.