ArticleRegional anesthesia and pain medicine2025
Brief pain reprocessing therapy for fibromyalgia: a feasibility, acceptability, and preliminary efficacy pilot.
Article in Regional anesthesia and pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Exposure-based Interventions for Chronic Pain and Bodily Symptoms: A Special Interest Meeting Report.Behaviour research and therapy · 2026Article
- Examining secondary outcomes after brief pain reprocessing therapy: improvements in mood disturbance and fatigue and their relationship to pain intensity.Regional anesthesia and pain medicine · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundFibromyalgia (FM) is a common, disabling, and costly nociplastic pain condition. Most frontline treatments show modest effects in reducing pain in FM, which may be due to a mismatch between the mechanisms of existing interventions and mechanisms underlying nociplastic pain. The current study was a single-arm, open-label trial examining the feasibility, acceptability, and preliminary efficacy of a novel, three-session telehealth behavioral intervention (Brief Pain Reprocessing Therapy (BPRT)). BPRT incorporates psychological techniques specifically targeting the putative mechanisms of nociplastic pain in a brief, telehealth format.
methods35 adults with FM initiated treatment. Participants were asked to complete three one-on-one intervention sessions via telehealth and online questionnaires at four time points (pre-intervention and at 1, 2, and 3 months post-intervention) assessing average pain intensity, pain interference, and pain-related fear.
results33 participants (94.3%) completed the BPRT protocol. Acceptability ratings for BPRT were high (62.0 out of 70 on the Treatment Acceptability/Adherence Scale). BPRT completers reported significant reductions in average pain intensity (B=-0.645, 95% CI -0.896 to -0.395, p<0.001; 1-month d=0.56, 2-month d=0.80, 3-month d=0.89), pain interference (B=-2.19, 95% CI -3.06 to -1.31, p<0.001; 1-month d=0.76, 2-month d=1.02, 3-month d=1.06), and pain-related fear (B=-2.29, 95% CI -3.07 to -1.51, p<0.001; 1-month d=0.60, 2-month d=0.88, 3-month d=1.04). At the 3-month follow-up, 42.3% of completers reported being 'much improved' or 'very much improved.'
conclusionsBPRT is feasible and acceptable, with promising preliminary efficacy for reducing pain, pain interference, and pain-related fear in FM. These findings highlight the possibility of reducing FM pain and interference using a brief telehealth intervention. Larger randomized controlled trials are needed to rigorously evaluate the efficacy and mechanisms of BPRT.
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