Evidence map›Paper›PMID 40973260›Full record

ArticleCarbohydrate polymers2025

A versatile and efficient method to quantify purity and degree of substitution in alginate derivatives.

Mabel Barreiro Carpio, Peter M Thompson, Christopher Moody, Joshua G Pierce, Yevgeny Brudno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mabel Barreiro CarpioDepartment of Chemistry, North Carolina State University, Raleigh, NC, USA.
Peter M ThompsonMolecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC, USA; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, USA.
Christopher MoodyJoint Department of Biomedical Engineering, University of North Carolina - Chapel Hill and North Carolina State University, Raleigh, 911 Oval Drive, Raleigh, NC 27695, USA; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina - Chapel Hill, Chapel Hill, NC 27599, USA.
Joshua G PierceDepartment of Chemistry, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: jgpierce@ncsu.edu.
Yevgeny BrudnoDepartment of Chemistry, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Joint Department of Biomedical Engineering, University of North Carolina - Chapel Hill and North Carolina State University, Raleigh, 911 Oval Drive, Raleigh, NC 27695, USA; Lineberger Comprehensive Cancer Center, University of North Carolina - Chapel Hill, 450 West Dr., Chapel Hill, NC 27599, USA; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina - Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: ybrudno@email.unc.edu.

Funding

Synthesis and Chemical Biology of Bioactive Natural ProductsR35GM139583 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIERCE, JOSHUA G. · 2021 to 2025
$2.5M
NIGMS NIH HHS R35 GM139583
6 · The paper itself

Abstract

Alginates, versatile polysaccharides extensively utilized in biomedical applications, require chemical modification to enhance their functionality for drug delivery, cell encapsulation, and tissue engineering. Despite their growing importance, the field has been hampered by inadequate analytical methods to assess product quality and accurately determine the degree of substitution (DS). While solution

Indexed as

AlginatesMagnetic Resonance SpectroscopyProton Magnetic Resonance SpectroscopyReproducibility of ResultsAlginates(1)H NMRAlginateAzideCarbodiimide couplingClick chemistryDOSYElemental analysis

Identifiers

PMID40973260
PMCPMC12481235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.