Evidence map›Paper›PMID 40973238›Full record

ReviewCurrent topics in developmental biology2025

Development and regeneration of Merkel cells.

Yudong Zhou, Elena Ezhkova

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yudong ZhouBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Elena EzhkovaBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: elena.ezhkova@mssm.edu.

Funding

Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2M
Toward Understanding the Role of the Polycomb Complex in Skin ControlR01AR069078 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EZHKOVA, ELENA · 2016 to 2024
$4.4M
Cellular and Molecular Mechanisms Underlying Merkel Cell Loss and RegenerationR01AG089916 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova, Hongzhen Hu · 2024 to 2026
$1.8M
NIAMS NIH HHS P30 AR079200NIAMS NIH HHS R01 AR069078NIA NIH HHS R01 AG089916
6 · The paper itself

Abstract

Merkel cells are epidermal mechanosensory cells that are crucial for transducing light touch sensations. The development of Merkel cells is influenced by various signaling pathways and is tightly regulated at the transcriptional and epigenetic levels. While studies have shed light on how Merkel cells develop, there is limited understanding of their maintenance in adulthood and their roles in maintaining our health. Intriguingly, emerging research on Merkel cells is slowly uncovering their functions in chronic itch, alloknesis, and potentially cancer, thereby promoting our understanding of their role in various disease states.

Indexed as

Merkel CellsRegenerationAnimalsHumansSignal TransductionMechanosensationMerkel cellPIEZO2Polycomb repressive complexRegenerationSkinTouch dome

Identifiers

PMID40973238
PMCPMC13454637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.