Evidence map›Paper›PMID 40973233›Full record

ReviewCurrent topics in developmental biology2025

Developing and regenerating a sense of taste.

Christina M Piarowski, Trevor J Isner, Linda A Barlow

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Expression ofbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christina M PiarowskiDepartment of Cell and Developmental Biology, Graduate Program in Cell Biology, Stem Cells, and Development, and the Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Trevor J IsnerDepartment of Cell and Developmental Biology, Graduate Program in Cell Biology, Stem Cells, and Development, and the Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Linda A BarlowDepartment of Cell and Developmental Biology, Graduate Program in Cell Biology, Stem Cells, and Development, and the Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. Electronic address: linda.barlow@CUAnschutz.edu.

Funding

Characterization of progenitor populations in adult taste epitheliumR01DC018489 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2020 to 2024
$2.5M
Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
The role of Kit signaling in taste bud regenerationR01DC021865 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Linda A Barlow · 2024 to 2026
$1.8M
Development of human taste organoid modelsR21DC022075 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2024 to 2024
$429k
Identifying Sox9 as a marker of multipotent progenitors in Circumvallate papilla/Von Ebner's gland homeostasisF31DC021632 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Trevor Joseph Isner · 2024 to 2026
$115k
Not so sweet: Investigating the role of c-Kit in sweet cell homeostasisF31DC020634 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI PIAROWSKI, CHRISTINA M · 2022 to 2024
$108k
NIDCD NIH HHS F31 DC020634NIDCD NIH HHS F31 DC021632NIDCD NIH HHS R01 DC018489NIDCD NIH HHS R01 DC021865NIDCD NIH HHS R21 DC022075NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

Gustation, or the sense of taste, is essential for distinguishing harmful and nutritious substances, and therefore crucial for health and survival. Taste buds (TBs) located in specialized gustatory papillae on the dorsal surface of the tongue are assemblages of specialized epithelial cells called taste receptor cells (TRCs). With the help of saliva, TRCs transduce sweet, sour, salt, bitter and umami stimuli into electrochemical signals that are transmitted to the brain via gustatory sensory neurons of the VII

Indexed as

RegenerationTasteTaste BudsAnimalsHumansadult stem cellsdevelopmentdysgeusiaGustationhomeostasisregenerationtaste buds

Identifiers

PMID40973233
PMCPMC12885093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.