Evidence map›Paper›PMID 40973121›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2026

The activity of combinations of currently used antigiardial drugs against Giardia duodenalis.

Keely Fayd'Herbe, Chun Kit Lam, Christopher J S Hart, Tina S Skinner-Adams

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Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keely Fayd'HerbeInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, 4111, Australia.
Chun Kit LamInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, 4111, Australia.
Christopher J S HartInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, 4111, Australia.
Tina S Skinner-AdamsInstitute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, 4111, Australia.ORCID 0000-0001-7011-3850

Funding

Australian National HealthMedical Research Council 2027850
6 · The paper itself

Abstract

backgroundDrug-combination therapies are needed to combat treatment refractory giardiasis. However, data describing the activity of combinations of currently used drugs against Giardia duodenalis are unavailable.

methodsThe in vitro activity of combinations of currently used antigiardial drugs were investigated against G. duodenalis.

resultsCombinations of metronidazole with albendazole or quinacrine, and quinacrine with nitazoxanide, behaved additively, whereas combinations of metronidazole with nitazoxanide, albendazole or quinacrine behaved synergistically. Combinations of albendazole with nitazoxanide behaved antagonistically.

conclusionsWhile combinations of metronidazole with nitazoxanide, or albendazole with quinacrine, may be effective treatments of giardiasis, combinations of albendazole with nitazoxanide are likely to result in negative pharmacodynamic interactions.

Indexed as

Antiprotozoal AgentsGiardia lambliaGiardiasisQuinacrineThiazolesAlbendazoleAnimalsDrug SynergismDrug Therapy, CombinationHumansMetronidazoleNitro CompoundsAlbendazoleAntiprotozoal AgentsMetronidazolenitazoxanideNitro CompoundsQuinacrineThiazolesdrug combinationsGiardiatreatment-refractory giardiasis

Identifiers

PMID40973121
PMCPMC12766445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.