Evidence map›Paper›PMID 40972890›Full record

ArticleContemporary clinical trials2025

The psychosocial pain management to improve opioid use disorder treatment outcomes study: Protocol for a randomized controlled trial.

Mark Ilgen, Frederic Blow, John D Piette, Jason Goldstick, Mandy Lewis, William Priest, Harshpreet Matharu, Michael Bourgoise, Chelsea Young, Doctor Ashe and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04433975 (Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04433975 nacompletednot on this map

Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of MichiganRan2020 to 2025Enrolled200ConditionsOpioid-use Disorder, Medication Assisted Treatment, Chronic PainArmsPsychosocial Pain Management (PPMI), Enhanced Usual Care (EUC)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mark IlgenDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA. Electronic address: marki@med.umich.edu.
Frederic BlowDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
John D PietteCenter for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA; Department of Health Behavior & Health Equity, University of Michigan School of Public Health, 1415 Washington Hts, Ann Arbor, MI 48109, USA.
Jason GoldstickDepartment of Emergency Medicine, University of Michigan School of Medicine, 2800 Plymouth Road, Suite G080, Ann Arbor, MI 48109, USA.
Mandy LewisDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
William PriestDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
Harshpreet MatharuDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
Michael BourgoiseDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
Chelsea YoungDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
Doctor AsheDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
Amanda PriceDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.
Lewei Allison LinDepartment of Psychiatry, University of Michigan School of Medicine, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, 2800 Plymouth Road, Building 16, Ann Arbor, MI 48109, USA.

Funding

Enhancing the impact of behavioral pain management on MAT outcomesR01AT010797 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ILGEN, MARK A., LIN, LEWEI ALLISON · 2019 to 2019
$3.2M
Psychosocial pain management to improve opioid use disorder treatment outcomesR33AT010106 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ILGEN, MARK A. · 2019 to 2020
$1.5M
Psychosocial pain management to improve opioid use disorder treatment outcomesR21AT010106 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ILGEN, MARK A. · 2018 to 2018
$298k
EPA EP-C-18-008HSRD VA IK6 HX002841NCCIH NIH HHS R01 AT010797NCCIH NIH HHS R21 AT010106NCCIH NIH HHS R33 AT010106
6 · The paper itself

Abstract

backgroundPeople with opioid use disorder (OUD) often experience comorbid chronic pain, which complicates treatment of both conditions. Medications for opioid use disorders (MOUD), specifically buprenorphine, are the standard of care for OUD and can be helpful for pain; however, a major challenge to sustaining effectiveness has been limited retention in buprenorphine treatment. Prior research has highlighted the efficacy of psychosocial treatments for pain management; although, research remains limited on integrated approaches to improve OUD outcomes among people/patients with chronic pain. This randomized controlled trial, called the Persist Study, investigated whether a psychosocial pain management intervention (PPMI) was more effective than Enhanced Usual Care (EUC) for MOUD patients with chronic pain.

methodsThis was a randomized trial of remotely delivered PPMI vs EUC for adults receiving MOUD who have chronic pain. Our study recruited nationally from MOUD clinics and through targeted online advertisements. Target enrollment was 200 participants randomly assigned to either PPMI (n = 100) or EUC (n = 100) conditions. The PPMI consisted of eight 1-h sessions and the EUC included two 15-min sessions conducted over a 6-week timespan. Primary outcomes measured retention on buprenorphine over 3 months, whereas secondary outcomes measured longer-term MOUD retention, pain level, pain-related functioning, and frequency of substance use over 12 months. DISCUSSION: The Persist Study tested a remotely delivered, manualized, psychosocial intervention for co-occurring chronic pain in patients prescribed buprenorphine treatment for OUD. Study results will inform efforts to improve retention and treatment outcomes among patients receiving MOUD who also have chronic pain.

trial registrationThis clinical trial has been registered with ClincialTrials.gov under ID NCT04433975.

Indexed as

BuprenorphineChronic PainOpioid-Related DisordersPain ManagementPsychosocial InterventionAdultAnalgesics, OpioidFemaleHumansMaleMulticenter Studies as TopicOpiate Substitution TreatmentRandomized Controlled Trials as TopicTreatment OutcomeAnalgesics, OpioidBuprenorphineChronic painCognitive behavioral therapyMedications for opioid use disorderOpioid dependenceSubstance use disorders

Identifiers

PMID40972890
PMCPMC12478605

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.