Evidence map›Paper›PMID 40972527›Full record

ArticleMolecular cell2025

RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity.

Tong Xiao, Dan He, Danqian Liu, Shang Jia, Qingyi Chen, Daniel Silverman, Neilabjo Maitra, Alan Y Huang, Aidan Pezacki, Trisha T Nguyen and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Cuproptosis and the bioinorganic basis of copper-induced cell death.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  2. Article
  3. Article
  4. Copper Import via CTR1 Supports the β3-Adrenergic Thermogenic Program.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tong XiaoDepartment of Chemistry, Princeton University, Princeton, NJ, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Dan HeDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.
Danqian LiuDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Shang JiaDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Qingyi ChenDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Daniel SilvermanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Neilabjo MaitraDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Alan Y HuangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Aidan PezackiDepartment of Chemistry, Princeton University, Princeton, NJ, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Trisha T NguyenDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Guodong RaoDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Rachel TillageDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.
Kelly DengDepartment of Chemistry, Princeton University, Princeton, NJ, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
David WeinshenkerDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.
R David BrittDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Mark J S KellyDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Yang DanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Christopher J ChangDepartment of Chemistry, Princeton University, Princeton, NJ, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: chrischang@princeton.edu.

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Chemical Probes to Study Methionine Redox BiologyR01GM139245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2020 to 2026
$2.9M
A 600 MHz NMR console and cryoprobe for studies of macromolecules, drug discovery and cancer biomarkersS10OD023455 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, JOHN D · 2018 to 2018
$820k
NIGMS NIH HHS R01 GM079465NIGMS NIH HHS R01 GM139245NIGMS NIH HHS R35 GM126961NIH HHS S10 OD023455
6 · The paper itself

Abstract

Increasing brain complexity is a major step in the evolution of species. Here, we show that, in the transition from amphibians to reptiles, the DNA repair protein RAD23B acquires a metalloadaptor function that allows it to serve as a central hub for both metabolism and protection of genomic integrity. More specifically, RAD23B gains an allosteric H274/H323 copper-binding site to enable the transfer of copper from the universal copper transporter 1 (CTR1) uptake protein to all known copper metallochaperone pathways, while simultaneously making its canonical functions in DNA repair copper dependent. This layer of nutrient regulation allows organisms to withstand elevated levels of potentially toxic copper while augmenting metabolism in cells with high energetic needs across both physiology and disease, including neurons in the locus coeruleus, a key brain structure that regulates sleep, and cancer cells.

Indexed as

AmphibiansCopperDNA-Binding ProteinsGenomic InstabilityAnimalsBinding SitesCopper Transporter 1DNA RepairEvolution, MolecularHumansNeuronsCopperCopper Transporter 1DNA-Binding ProteinsAmniota evolutionCTR1/SLC31A1metalloadaptormetalloallosterymitochondrial metabolismRad23bsleep and wake behaviortransition metal signaling

Identifiers

PMID40972527
PMCPMC12453601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.