Evidence map›Paper›PMID 40972303›Full record

ArticleJournal of colloid and interface science2026

Characterization of lipid solubilization, bicelle formation, and magnetic-alignment induced by saponins.

Samuel D McCalpin, Kailey Kassinger, Madison Gilmore, Ayyalusamy Ramamoorthy

Abstract read
In one paragraph

Article in Journal of colloid and interface science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in pharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel D McCalpinDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL 32310, USA; National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32304, USA.
Kailey KassingerDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL 32310, USA; National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA.
Madison GilmoreDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL 32310, USA; National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA.
Ayyalusamy RamamoorthyDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL 32310, USA; National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32304, USA. Electronic address: aramamoorthy@fsu.edu.

Funding

Development of biophysical approaches to investigate high-resolution structure and dynamics of membrane proteinsR35GM139573 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ayyalusamy Ramamoorthy · 2021 to 2026
$2.0M
NIGMS NIH HHS R35 GM139573
6 · The paper itself

Abstract

Saponins are a diverse class of plant-derived glycoside natural products. They are amphiphilic surfactants and have been included in food, agriculture, cosmetics, cleaner, and pharmaceutical products as emulsifiers. Interactions between saponins and lipids have been widely studied for these applications. Recently, some binary saponin-phospholipid mixtures have been reported to form disc-shaped colloidal particles, called bicelles or nanodiscs, that align in a magnetic field. These bicelles are potentially useful for a variety of research and biomedical purposes. Here, we used transmittance assays to determine the ability of Quillaja saponins (CQS) to solubilize phospholipids with varied chain lengths and headgroup charges. Then, we used static

Indexed as

PhospholipidsQuillaja SaponinsSaponinsParticle SizeQuillajaSolubilityPhospholipidsQuillaja SaponinsSaponinsBicelleLipidMagnetic alignmentNanodiscNMRSaponin

Identifiers

PMID40972303
PMCPMC12799272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.