ArticlePLoS neglected tropical diseases2025
Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Early enhanced control ofInfection and immunity · 2026Article
- Cellular nucleic acid-binding protein (CNBP) dependent cytokine programming shapes host defense againstbioRxiv : the preprint server for biology · 2026Article
- Early enhanced control ofbioRxiv : the preprint server for biology · 2026Article
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9 authors.
Funding
Abstract
Subclinical parasitemia constitutes the predominant proportion of Plasmodium spp. infections in hyperendemic regions of the world. Elevated levels of serum interleukin-10 (IL-10) are observed in both acute symptomatic and chronic subclinical Plasmodium spp. infections. The role of IL-10 in acute infection has been extensively studied; however, the role of sustained elevated levels of IL-10 in chronic subclinical plasmodial infections remains to be determined. We investigated the role of IL-10 in a long-term subclinical and patent Plasmodium chabaudi chabaudi-AS (Pc) infection using mice lacking humoral immunity (µMT-/- mice). Pc-infected µMT-/- mice exhibit a long-term (99 days) chronic infection, with microscopic levels of parasitemia and without any outward signs of disease. We found that chronically infected mice have slightly elevated levels of tumor necrosis factor α (TNFα) and interferon-γ (IFNγ), and high levels of IL-10 in the circulation. The source of IL-10 was CD4+ T cells. We found that elevated IL-10 levels were mechanistically linked to subclinical Plasmodium infection by blocking IL-10 signaling. Anti-IL-10R resulted in a marked, albeit transient, reduction of the parasitemia that was accompanied by a robust pro-inflammatory response and death of chronically infected µMT-/- mice. A similar outcome was observed in infected µMT-/- mice after CD4+ T cell depletion with anti-CD4 antibody. CD4-depleted infected µMT-/- mice exhibited reduced IL-10 and rapid weight loss, succumbing to infection by day 6 after CD4 neutralization. Our results showed that IL-10 from CD4+ T cells limits immune-mediated pathology in chronic subclinical Pc infection in µMT-/- mice by protecting against excessive inflammatory responses to blood-stage parasites.
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