ArticleAmerican journal of hypertension2026
Association Between ABPM Phenotypes and Cognitive Impairment in a Community-Dwelling, Older Adult Population Taking Antihypertensive Medication: A Pilot Study.
Article in American journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Recent developments and challenges in hypertensive dementia over the past year.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
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6 authors.
Funding
Abstract
backgroundHypertension (HTN) is associated with an increased risk of cognitive impairment (CI). This study aimed to explore the relationship between Ambulatory BP Monitoring (ABPM) phenotypes and CI in a predominantly Black, older adult population.
methodsThis cross-sectional study enrolled adults ≥60 years of age with HTN and taking ≥1 antihypertensive. Participants had 3 seated BP readings taken 1 minute apart, followed by 24-hour ABPM. Cognitive impairment was determined using the Mini-Mental State Examination (MMSE-2) with a cutoff score of ≤25. 24-hour ABPM control was defined as <125/75, and seated BP control was defined as <130/80 mm Hg. A sleep BP decline of <10% was used to identify non-dippers. ABPM phenotypes were compared to categorical data measured by the MMSE-2 and analyzed using the Chi-square test. Unadjusted and adjusted (age and gender) prevalence ratios were also calculated.
resultsThe 69 participants included in the analysis had a mean age of 69 years, 56.5% were female, and 73.9% identified as Black/African American. Cognitive impairment was identified in 29% (n = 20) of the participants according to their MMSE-2 score. Cognitive impairment prevalence was significantly higher among participants exhibiting a non-dipping BP pattern (75% vs 40.8%; P = .01), elevated sleep diastolic BP (P = .02), and 24-hour, awake, sleep, and seated heart rate (P < .05 for all).
conclusionsSleep BP and heart rate were associated with a higher prevalence of CI and may offer clues as to the underlying pathophysiology of BP-associated CI. These findings warrant further study in a larger population followed longitudinally.
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