Evidence map›Paper›PMID 40971968›Full record

ArticlePLoS neglected tropical diseases2025

MoLEP-Co-creating a Mycobacterium leprae transmission interruption program for the Morogoro region, Tanzania.

Tanja Barth-Jaeggi, Guy de Coulon, Issa Garimo, John Msaki, Liberate Mleoh, Riziki Kisonga, Sunil Modali, Shaishav Panchal, Shigela Marco Njebele, Shamez Sunderji and 2 more

Abstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tanja Barth-JaeggiSwiss Tropical and Public Health Institute, Allschwil, Switzerland.ORCID 0000-0002-4453-5950
Guy de CoulonNovartis Kenya Ltd., Nairobi, Kenya.
Issa GarimoGerman Leprosy and Tuberculosis Relief Association Tanzania, Dar es Salaam, Tanzania.
John MsakiNational Tuberculosis and Leprosy Programme, Dodoma, Tanzania.
Liberate MleohNational Tuberculosis and Leprosy Programme, Dodoma, Tanzania.
Riziki KisongaNational Tuberculosis and Leprosy Programme, Dodoma, Tanzania.
Sunil ModaliNovartis Pharmaceuticals, London, United Kingdom.
Shaishav PanchalNovartis Healthcare Pvt. Ltd., Hyderabad, India.
Shigela Marco NjebelePresident's Office - Regional Administration and Local Government, Dodoma, Tanzania.
Shamez SunderjiGerman Leprosy and Tuberculosis Relief Association Tanzania, Dar es Salaam, Tanzania.
Kihulya MagedaPresident's Office - Regional Administration and Local Government, Dodoma, Tanzania.
Peter SteinmannSwiss Tropical and Public Health Institute, Allschwil, Switzerland.

Funding

Novartis
6 · The paper itself

Abstract

The global goal for leprosy elimination is the interruption of Mycobacterium leprae transmission, resulting in zero new leprosy patients. In alignment with this objective, Tanzania's updated national leprosy strategy emphasizes early detection, systematic contact tracing, post-exposure prophylaxis (PEP) with single-dose rifampicin (SDR), and integration of services into primary health care. However, the feasibility of accelerating M. leprae transmission interruption in high-burden areas with this strategy has yet to be demonstrated. In 2024, the Morogoro Leprosy Elimination Program (MoLEP) was launched in the country's most endemic region. Developed through a collaborative process, MoLEP aligns global practices with local conditions and needs. Key interventions include training frontline health workers and expanding contact tracing with SDR-PEP. Furthermore, targeted activities will respond to high transmission areas and the detection of child cases, which serve as indicators of recent transmission. Strengthening the drug supply chain is also a priority. MoLEP will generate critical data on the feasibility and effectiveness of these interventions in accelerating progress toward elimination. The implementation is guided by a comprehensive monitoring and evaluation framework, alongside clearly defined governance structures, to facilitate evidence-informed decision-making. Findings are expected to guide strategic scaling and replication in other high-burden regions across Tanzania and beyond.

Indexed as

Contact TracingDisease EradicationEndemic DiseasesLeprosyPost-Exposure ProphylaxisEpidemiological MonitoringFeasibility StudiesHumansLeprostatic AgentsRifampinTanzaniaLeprostatic AgentsRifampin

Identifiers

PMID40971968
PMCPMC12448972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.