ArticlePloS one2025
Effect of Omega 3 supplementation during pregnancy and lactation on cognitive functions in rat offspring.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
aimThis study investigates the effects of omega-3 supplementation starting in the preconception period, during the 1st, 2nd, and 3rd weeks of pregnancy, and lactation on the cognitive functions of rat offspring.
methodsThe study involved 30 mother rats divided into a test group receiving 400 mg/kg/day omega-3 supplementation via oral gavage and a control group with no supplementation. Omega-3 supplementation began at different stages for each group and continued through the lactation period (21 days). Two male pups from each mother, for a total of 60 pups, were tested for cognitive function at 45 days using the Morris Water Maze to assess spatial learning and reference memory.
resultsSignificant differences were found between groups in initial weights, pre-mating weights, pre-birth weights, number of pups, and gestation duration (p < 0.05), but not in weight gain during pregnancy (p > 0.05). The time to find the platform on test days 1 and 2 was significantly different between groups (p < 0.05). Differences in platform-finding times across trials were also significant (p < 0.05). However, no significant difference was found in the probe test on day 5 (p > 0.05).
conclusionInitiating omega-3 supplementation during the early stages of pregnancy may be more effective for both short-term and long-term memory.
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