Evidence map›Paper›PMID 40971723›Full record

Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2025

An empirical test of the Information-Motivation-Behavioral Skills model of willingness and intention to use HIV pre-exposure prophylaxis among adolescent men who have sex with men.

Hannah Yellin, Yan Wang, David M Huebner, Carlos E Rodríguez-Díaz, Kathryn Macapagal, Michael E Newcomb, Brian Mustanski, Monica S Ruiz

Registry-linked trialAbstract readPragmatic Clinical TrialRandomized Controlled Trial
In one paragraph

Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511131 (A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03511131 nacompletednot on this map

A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM

TypeinterventionalSponsorNorthwestern UniversityRan2018 to 2021Enrolled1,306ConditionsHiv, Adolescent Behavior, Sex, SafeArmsQueer Sex Ed, Keep It Up, Keep It Up-Control, Young Men's Health Project
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah YellinDepartment of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20037, United States.ORCID 0000-0002-4880-3270
Yan WangDepartment of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20037, United States.
David M HuebnerDepartment of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20037, United States.ORCID 0000-0001-6006-5146
Carlos E Rodríguez-DíazDepartment of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20037, United States.ORCID 0000-0001-6333-0654
Kathryn MacapagalDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States.ORCID 0000-0002-1208-6097
Michael E NewcombDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States.ORCID 0000-0002-8431-2946
Brian MustanskiDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States.ORCID 0000-0001-9222-5116
Monica S RuizDepartment of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20037, United States.

Funding

A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSMU01MD011281 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MUSTANSKI, BRIAN · 2016 to 2020
$9.7M
NIH HHSNIMHD NIH HHS U01 MD011281
6 · The paper itself

Abstract

backgroundAdolescent men who have sex with men (AMSM) are disproportionately affected by HIV, yet uptake of HIV pre-exposure prophylaxis (PrEP) among AMSM is low. Theory-based research is needed to increase PrEP adoption for HIV prevention among AMSM. PURPOSE: Using the Information-Motivation-Behavioral Skills (IMB) model, we aimed to (1) examine information, motivation, and behavioral skills as determinants of willingness and intention to use PrEP and (2) determine whether these relationships were moderated by depressive symptoms and substance use.

methodsA secondary analysis was performed using cross-sectional baseline data from 1,364 AMSM ages 13-18 who participated in the SMART eHealth HIV prevention intervention between 2018 and 2020. Structural equation modeling and multigroup analysis were used to investigate the aims.

resultsInformation and social motivation were indirectly associated with PrEP willingness and intention through behavioral skills. Personal motivation was directly associated with PrEP willingness and intention. Depressive symptoms and substance use were not moderators.

conclusionsAMSM who were more informed about and socially motivated to take PrEP had stronger PrEP-related behavioral skills, and in turn were more likely to be willing and have an intention to use PrEP. AMSM who were more personally motivated to use PrEP were more likely to be willing and have an intention to use PrEP. Results suggest that the IMB model may remain robust in the presence of depression and substance use. These findings support the use of the IMB model in interventions designed to promote PrEP uptake among AMSM. CLINICAL TRIALS REGISTRATION NUMBER: NCT03511131.

Indexed as

Health Knowledge, Attitudes, PracticeHIV InfectionsHomosexuality, MaleIntentionModels, PsychologicalMotivationPatient Acceptance of Health CarePre-Exposure ProphylaxisAdolescentCross-Sectional StudiesDepressionHumansInformation Motivation Behavioral Skills ModelMaleSubstance-Related DisordersadolescentsHIV preventionIMB modelPrEPsexual minority health

Identifiers

PMID40971723
PMCPMC12448465

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.