Evidence map›Paper›PMID 40971441›Full record

ArticleScience advances2025

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism.

Audrey Desgrange, Emeline Perthame, Carmen Marchiol, Daphné Madec, Laurent Guillemot, Marie-Amandine Chabry, Mohamed El Beheiry, Jean-Baptiste Masson, Olivier Raisky, Ségolène Bernheim and 2 more

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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Audrey DesgrangeUniversité Paris Cité, Paris 75006, France.ORCID 0000-0001-9716-755X
Emeline PerthameUniversité Paris Cité, Paris 75006, France.ORCID 0000-0002-8266-5908
Carmen MarchiolUniversité Paris Cité, Paris 75006, France.
Daphné MadecUniversité Paris Cité, Paris 75006, France.ORCID 0009-0003-2760-3813
Laurent GuillemotUniversité Paris Cité, Paris 75006, France.ORCID 0000-0002-5979-5501
Marie-Amandine ChabryUniversité Paris Cité, Paris 75006, France.
Mohamed El BeheirySorbonne Université, Institut Curie, PSL Research University, CNRS UMR 168 Physico-Chimie Curie, Paris 75005, France.ORCID 0000-0001-9827-6619
Jean-Baptiste MassonUniversité Paris Cité, Paris 75006, France.ORCID 0000-0002-5484-9056
Olivier RaiskyUniversité Paris Cité, Paris 75006, France.
Ségolène BernheimUniversité Paris Cité, Paris 75006, France.ORCID 0000-0003-3506-6184
Lucile HouyelUniversité Paris Cité, Paris 75006, France.ORCID 0000-0003-4024-8599
Sigolène M MeilhacUniversité Paris Cité, Paris 75006, France.ORCID 0000-0003-4080-2617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heart functions in two parallel but asymmetric circulations, driven by the right and left ventricles. In the heterotaxy syndrome, abnormal left-right patterning leads to a spectrum of severe congenital heart defects, including ventricle malposition. A postulate anchored in the clinical nomenclature assumes that the looping direction of the embryonic heart tube determines ventricle position at birth. However, this has not been demonstrated experimentally. Here, we performed a unique longitudinal analysis of heterotaxy with right isomerism, using multimodality imaging of

Indexed as

HeartHeart Defects, CongenitalHeart VentriclesHeterotaxy SyndromeAnimalsHumansMice

Identifiers

PMID40971441
PMCPMC12448140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.