ArticleScience advances2025
Personalized mapping of inhibitory spinal cord circuits in humans via noninvasive neural decoding and in silico modeling.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Spinal motor neuron pools may be partly driven by impulsive common inputs.The Journal of physiology · 2026Article
- Article
- The variability of reflex amplitude estimates in motor unit pools depends on the phenotype distribution and discharge statistics.bioRxiv : the preprint server for biology · 2026Article
- Augmented and prematurely occurring H-reflex recovery curve shows enhanced spinal network excitability in ALS patients when employing the double stimulation paradigm.Frontiers in neurologyArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studying human motoneuron activity through electromyography (EMG) can yield insights into the operation of fundamental spinal cord microcircuits. Traditional surface and needle EMG methodologies have limited capacity to shed light on the diversity of motor unit (MU) control strategies that may be unique to each individual. Here, we used high-density surface EMG (HDsEMG) to sample multiple MUs per participant to investigate the features of inhibitory spinal microcircuits in both upper and lower limb control. We characterized the net inhibition as a function of individual MU firing rates, revealing participant-specific relationships. In silico modeling replicated these experimental characteristics and suggested that properties of the inhibitory currents rather than motoneuron size are responsible for net functional inhibition. Our results show that HDsEMG can highlight distinct control strategies across circuits and motor pools, revealing participant-specific properties of inhibitory spinal microcircuits.
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