Evidence map›Paper›PMID 40971386›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Sarah C Stanhope, Kratika Singhal, Nicolás M Morato, Yunfei Feng, Gaoya Meng, Makayla N Marlin, Claudia C Kotanko, Madolyn M Jarrett, Andrew D Mesecar, R Graham Cooks and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Biomolecules · 2026
    Review
  3. Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah C StanhopeDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-0746-2529
Kratika SinghalDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Nicolás M MoratoPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.
Yunfei FengDepartment of Chemistry, Purdue University, West Lafayette, IN 47907.
Gaoya MengDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-2318-9374
Makayla N MarlinDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Claudia C KotankoDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Madolyn M JarrettDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.ORCID 0009-0009-7572-8948
Andrew D MesecarDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
R Graham CooksPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-9581-9603
Vikki M WeakeDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-5933-9952

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Chromatin connects metabolism to circadian gene regulation in the aging eyeR01EY033734 · NEI · PURDUE UNIVERSITY · PI Vikki Marie Weake · 2023 to 2026
$1.5M
Purdue Drug Discovery Training ProgramT32GM125620 · NIGMS · PURDUE UNIVERSITY · PI DYKHUIZEN, EMILY CARLA, WEI, ALEXANDER · 2019 to 2023
$891k
New X-ray Diffractometer and Detector for Purdue Macromolecular CrystallographyS10OD030507 · OD · PURDUE UNIVERSITY · PI TESMER, JOHN · 2022 to 2022
$860k
Characterizing Ahcy as a redox regulated enzyme in the Drosophila eye under oxidative stressF31EY036754 · NEI · PURDUE UNIVERSITY · PI GREGOR, SARAH · 2024 to 2025
$99k
HHS | NIH | National Eye Institute (NEI) F31EY036754HHS | NIH | National Eye Institute (NEI) R01EY033734HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5T32GM125620NCI NIH HHS P30 CA023168NEI NIH HHS F31 EY036754NEI NIH HHS R01 EY033734NIGMS NIH HHS T32 GM125620NIH HHS S10 OD030507ODCDC CDC HHS S10 OD030507
6 · The paper itself

Abstract

One-carbon metabolism influences gene expression by providing methyl units for DNA, RNA, and histone methylation. Robust methylation requires rapid hydrolysis of the methylation by-product

Indexed as

AdenosylhomocysteinaseDrosophila melanogasterDrosophila ProteinsLightRetinal DegenerationAnimalsCaenorhabditis elegansGene Expression RegulationHumansHydrogen PeroxideOxidation-ReductionOxidative StressAdenosylhomocysteinaseDrosophila ProteinsHydrogen Peroxideone-carbon metabolismredox homeostasisredox-regulationretinal degenerationS-adenosylhomocysteinase (Ahcy)

Identifiers

PMID40971386
PMCPMC12478188

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.