ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
A Retrospective Cohort Study of Physical Activity and Survival in Patients Treated with Immune Checkpoint Inhibitors.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Review
- Psychological distress as a putative host-state determinant of cancer immunotherapy response.Frontiers in immunology · 2026Review
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6 authors.
Funding
Abstract
backgroundThe impact of physical activity in patients with cancer treated with immune checkpoint inhibitors (ICI), both of which affect outcomes via modulating the immune system, is unclear. We investigated associations between self-reported, pretreatment physical activity and survival in a series of patients with cancer treated with ICI.
methodsThis retrospective cohort study included 930 patients treated with ICI who previously reported physical activity and had good performance status at treatment initiation. Hazards of death associated with increasing quartile of physical activity, measured as weekly metabolic equivalent of task minutes derived from the International Physical Activity Questionnaire (IPAQ), were estimated by multivariable Cox proportional hazards models adjusting for covariates. Alternative measures of physical activity based on IPAQ and consensus guidelines were also assessed.
resultsIncreasing physical activity quartile was associated with a decreased adjusted hazard of death [adjusted HR (aHR) per one quartile increase, 0.89; 95% confidence interval (CI), 0.82-0.96]. Patients in the third and top quartile had a 24% (aHR = 0.76; 95% CI, 0.59-0.97) and 28% (aHR = 0.72; 95% CI, 0.55-0.93) reduced hazard of death compared with the bottom quartile, respectively. Results based on IPAQ and consensus guidelines and results from sensitivity analyses support findings from main analyses.
conclusionsPretreatment physical activity is associated with increased survival among patients with cancer treated with ICI. Observational studies incorporating objective measurement and randomized interventional trials are needed to further establish the role of physical activity in improving ICI outcomes. IMPACT: Physical activity may be a promising interventional strategy to accompany ICI therapy to improve patient outcomes.
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