ReviewAging and disease2025
Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation.
Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Osteoporosis from the perspective of the gut-bone axis: gut microbiota, metabolites, and multi-system synergistic regulation.Journal of endocrinological investigation · 2026Review
- Characterization of the gut phageome and functional genes carried by phages in laying hens with fatty liver hemorrhagic syndrome.Microbiome · 2026Article
- Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health.World journal of virology · 2026Review
- Article
- Fecal microbiota transplant and its usefulness in hepatic disorders: a systematic review.Therapeutic advances in gastroenterology · 2026Review
- The gut virome and regulatory T cell axis in health and systemic disease.Microbiome research reports · 2026Review
- The Human Virome in Health and Its Remodeling During HIV Infection and Antiretroviral Therapy: A Narrative Review.Microorganisms · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut harbors trillions of microbes that play essential roles in metabolism and immunological functions. The virome, an important but understudied component of the gut microbiota, comprises bacteriophages commonly referred to as bacterial viruses, among other inhabitants. Understanding the interplay between the gut virome and bacteria can illuminate the dynamics of microorganisms in both healthy and diseased states. This knowledge can open new avenues for treatment, such as phage therapy and microbiota modulation, which aim to restore balance in the gut and improve overall health. The composition and diversity of the gut microbiome and virome undergo significant changes, which have been linked to increased susceptibility to infections, chronic inflammation, and age-related disease. Exploring the gut virome's role in aging may provide insights into how viral and bacterial interactions influence immune senescence and gut resilience in the elderly population. This review provides an overview of the current understanding of the relationship between the gut virome, specifically phages associated with gut bacteria, and mechanisms of phage-host interactions, shedding light on how these factors affect and influence communities. Additionally, this review also explores the impact of the gut virome on gut resilience and its role in shaping and influencing the host's immune response. Maintaining a healthy gut requires a stable and robust virome. Therefore, future research on the virome is crucial for the development of microbe-based products that enhance human and animal health and aid in addressing specific diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.