Evidence map›Paper›PMID 40971184›Full record

SynthesisEpilepsia2026

Effects of cell therapy on seizures in animal models of epilepsy: Systematic review and meta-analysis.

Afaf S Altalhi, Muhammad S Javaid, Nigel C Jones, Kim L Powell, Patrick Kwan, Terence J O'Brien, Ana Antonic-Baker

Abstract readSystematic ReviewMeta-AnalysisReview
In one paragraph

Synthesis in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Afaf S AltalhiDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0009-0002-4625-3188
Muhammad S JavaidDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-2146-5566
Nigel C JonesDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-1080-8439
Kim L PowellDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-9007-4614
Patrick KwanDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-7310-276X
Terence J O'BrienDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-7198-8621
Ana Antonic-BakerDepartment of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-4275-7557

Funding

National Health and Medical Research Council APP2024363
6 · The paper itself

Abstract

This study was undertaken to systematically evaluate the efficacy of cell therapy in reducing seizures in animal models of chronic epilepsy. Three databases, Ovid MEDLINE, Ovid Embase, and Web of Science, were searched using predetermined eligibility criteria. The relevant preclinical controlled studies were included for review and meta-analysis using a random-effects model to calculate summary estimates of the effect size (percentage reduction in seizures). The degree of heterogeneity among the included studies was assessed using the I

Indexed as

Cell- and Tissue-Based TherapyDisease Models, AnimalEpilepsySeizuresAnimalsKainic AcidKainic Acidanimal modelcell therapycell transplantationepilepsyseizuresstem cells

Identifiers

PMID40971184
PMCPMC12893257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.