ArticleChemistryOpen2025
Molecular Networking-Driven Chemical Profiling, Characterization, and Antibacterial Effects of Cuo Nanoparticles Synthesized from Citrus Unshiu Peel Extract.
Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Molecular networking has emerged as a new in silico tool for analyzing liquid chromatography-mass spectrometry (LC-MS) data for better annotation and elucidation of novel compounds and different pathways. Green synthesized nanoparticles (NPs) have gained considerable attention as a result of their effectiveness in possessing good antimicrobial activity. Their eco-friendly nature and cost-effective synthesis have positioned them as sustainable nanomaterials in various fields. However, not much is known about the mechanism underlying the green synthesis of NPs. Therefore, herein, the copper oxide NPs (CuO NPs) are fabricated, and ultrahigh performance liquid chromatography-quadrupole time of flight mass spectrometry based molecular networking is utilized to understand the phytochemical relationship between the crude extract and the NPs, outlining metabolites that might be involved in reduction. Moreover, CuO NPs synthesized from Citrus unshiu fruit peels are tested for their antimicrobial and cytotoxic activities. Various characterization methods, such as X-ray diffraction, UV-vis spectroscopy, scanning electron microscopy-energy dispersive X-ray analysis, Fourier transform infrared, dynamic light scattering, and transmission electron microscopy, are employed to provide comprehensive insights into the atomic and structural characteristics of NPs. Molecular network reveals the presence of different metabolites such as isosakuranetin-7-O-rutinoside, hesperidin, skullcapflavone II, homoorientin, eupatorin-5-methylether, scoparin, and vitexin, which are recognized as antimicrobial and reducing agents. Additionally, the synthesized CuO NPs show exceptional antibacterial efficacy with a low minimum inhibitory concentration on Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Salmonella typhimurium, highlighting the potential of using LC-MS to explain the antimicrobial properties and green synthesis pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.