Evidence map›Paper›PMID 40971127›Full record

ArticleMolecular imaging and biology2025

Today's Research, Tomorrow's Practice - White Paper from the Translation of New Therapy (TNT) Radiotheranostics Kick-off Pre-meeting of the Annual World Molecular Imaging Conference 2024.

Simone Krebs, Lisa Baird, Giacomo Pirovano, Aiko Yamaguchi, Ryan P Coll, Jason T Lee, Laurence S Carroll, Martin G Pomper, H Charles Manning

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simone Krebs *Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. sskrebs@mdanderson.org.ORCID 0000-0002-9909-4531
Lisa Baird *World Molecular Imaging Society, 10736 Jefferson Blvd., #185 , Culver City, CA, USA. lbaird@wmis.org.
Giacomo PirovanoEvergreen Theragnostics, Springfield, NJ, USA.
Aiko YamaguchiDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ryan P CollDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jason T LeeMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Laurence S CarrollJohns Hopkins School of Medicine, Radiology, Baltimore, MD, USA.
Martin G PomperDepartment of Radiology, UT Southwestern, Dallas, TX, USA.
H Charles ManningDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten captureR37CA262557 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Simone Krebs · 2021 to 2026
$3.4M
IL13Ra2-targeted radioimmunotherapy for glioblastomaR21CA294042 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KREBS, SIMONE · 2025 to 2025
$432k
Cancer Prevention and Research Institute of Texas RP200046NCI NIH HHS R21 CA294042NCI NIH HHS R37 CA262557NIH HHS R21 CA294042NIH HHS R37 CA262557
6 · The paper itself

Abstract

Theranostics, a concept combining "therapy" and "diagnostics", is poised to enter an exponential growth phase. By using specific diagnostic markers to guide the selection and application of targeted treatments directed at those markers, this approach aims to improve effectiveness and reduce unnecessary interventions. While several agents have been approved by the FDA recently, multiple additional theranostics are being developed, studied in clinical trials and expected to enter clinical practice in short order. As part of the "Translation of New Therapy (TNT) Interest Group's Radiotheranostics Kick-off" pre-meeting of the annual World Molecular Imaging Conference (WMIC) 2024 over 350 attendees with 10% leaders from industry, 60% senior and junior investigators in academia and 30% trainees discussed the key challenges and opportunities in implementing a theranostic research program in academia, which are addressed in this white paper. Overarching themes included funding, regulatory hurdles, and workforce training. Panel recommendations included leveraging existing expertise and patient populations, securing revenue streams, exploring alternative funding sources, and developing a multifaceted approach to promote training, education and public awareness, including fostering academic-industry partnerships. By shedding light on the gap between research and real-world program implementation, this white paper and forthcoming pre-meetings at WMIC aim to define a practical framework for building successful programs based on insights from recent research.

Indexed as

Molecular ImagingTheranostic NanomedicineTranslational Research, BiomedicalCongresses as TopicHumansChallenges and opportunitiesTheranosticTranslational researchWhite paper

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.