Trial reportClinical oral investigations2025
Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Injectable platelet-rich fibrin (iPRF) and postoperative outcomes in mandibular impacted third molar surgery: a split-mouth randomized controlled trial.BMC oral health · 2026Trial
- Early Diagnosis of Iatrogenic Post-Traumatic Trigeminal Neuropathies: From Clinical Gaps to Medico-Legal Implications-A Comprehensive Structured Narrative Review.Journal of clinical medicine · 2026Review
- Review
- Platelet Concentrates in Alveolar and Periodontal Bone Regeneration: Adjunctive Benefits and Clinical Comparability with Conventional Approaches: A Systematic Review.Journal of clinical medicine · 2026Review
- Early Clinical Outcomes of Full-Arch Rehabilitations with Immediately Loaded Implants with Buccal Dehiscence Treated with Horizontal Augmentation: A 1-Year Retrospective Case Series.Dentistry journal · 2026Article
- Biomaterials in personalized drug delivery: innovations, challenges, and future directions.PeerJ · 2026Review
- Comparing the efficacy of A-PRF and I-PRF in mandibular 3rd molar surgery with similar difficulty index: A comparative, split mouth study.Bioinformation · 2026Article
- The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review.Frontiers in dental medicine · 2025Review
- Effect of platelet-rich fibrin in enhancing healing after impacted mandibular third molar extractions: A randomized controlled trial.Bioinformation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this RCT was to clinically evaluate swelling, pain and wound healing following submucosal infiltration of injectable Platelet-Rich Fibrin (i-PRF) after extraction of impacted lower third molar. MATERIALS AND
methodsThe study was designed as a double-blinded, parallel group, randomized controlled clinical trial. 56 patients were divided into 2 groups: in the control group the socket was left to heal spontaneously, while the test group was treated with submucosal infiltration of i-PRF. Swelling was measured with a flexible ruler using the diagonals joining Trago and Pogonion, Gonion and labial cleft. The swelling was calculated as the sum of these diagonals before surgery, on day 3 and 7. Pain was assessed by VAS scale until the 7th postoperative day. Surgical wound healing was evaluated by the Healing Index by Landry on 3, 7 ,14 and 21st day postosperatively. The relation between duration of intervention and total swelling was also evaluated.
results56 patients were enrolled in this study (28 for the test group and 28 for the control group). Randomization resulted in groups with similar baseline characteristics. No patients were lost during the follow-up and no adverse events were noted. On day 3 the total swelling was 12.7 ± 0.92 mm for control group and 12.1 ± 0.75 mm for test group; on day 7 it was 12.3 ± 0.88 mm for control group and 11.7 ± 0.73 mm for test group. A statistically significant difference was found on day 3 (p = 0.006) and on day 7 (p = 0.018). The relation between total swelling and duration of intervention was not statistically significant (p = 0.276). A significant reduction in pain scores was observed in the i-PRF group on days 1 and 3 (p < 0.001). Surgical wound healing also showed statistically significant improvement in the i-PRF group at all time points (days 3, 7, 14, and 21; p < 0.05).
conclusionsWithin the limit of our study, this randomized controlled clinical trial suggests that submucosal infiltration of i-PRF after the extraction of impacted lower third molars effectively reduces postoperative swelling and pain, while also promoting faster wound healing. CLINICAL RELEVANCE: The adjunctive use of injectable platelet-rich fibrin (i‑PRF) after surgical removal of impacted mandibular third molars may contribute to improve early postoperative outcomes by attenuating soft tissue inflammation, reducing pain intensity, and accelerating wound healing. By potentially lowering the need for nonsteroidal anti-inflammatory drugs (NSAIDs) and minimizing associated adverse effects, i‑PRF represents a minimally invasive, autologous approach that could enhance patient comfort, reduce recovery time, and support faster return to daily activities.
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