Evidence map›Paper›PMID 40970998›Full record

ArticleImmunologic research2025

Monocyte plasticity and HLA-DR expression in patients with X-linked agammaglobulinemia.

Hasibe Artac, Ayca Ceylan, Ilknur Kulhas Celik, Figen Celebi Celik, Yasin Karali, Zeynep Meric, Demet Tekcan, Mehmet Geyik, Selcen Bozkurt, Saliha Esenboga and 19 more

Abstract read
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Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Hasibe ArtacDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey. artachasibe@gmail.com.
Ayca CeylanDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey.
Ilknur Kulhas CelikDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey.
Figen Celebi CelikDivision of Immunology and Allergy, Department of Pediatrics, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
Yasin KaraliDivision of Immunology and Rheumatology, Department of Pediatrics, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Zeynep MericDivision of Immunology and Allergy, Department of Pediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Demet TekcanDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey.
Mehmet GeyikDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
Selcen BozkurtDivision of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey.
Saliha EsenbogaDivision of Immunology and Allergy, Department of Pediatrics, Ihsan Dogramacı Children's Hospital, Hacettepe University, Ankara, Turkey.
Zehra Şule HaskoloğluDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ankara University, Ankara, Turkey.
Esra Ozek YucelDivision of Immunology and Allergy, Department of Pediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Nesrin GulezDivision of Immunology and Allergy, Department of Pediatrics, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
Neslihan Edeer KaracaDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
Sevgi Bilgic EltanDivision of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey.
Sukru Nail GunerDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Cigdem AydogmusDivision of Immunology and Allergy, Department of Pediatrics, Basaksehir Cam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey.
Mehmet Halil CeliksoyDivision of Immunology and Allergy, Department of Pediatrics, Basaksehir Cam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey.
Esra KarabiberDivision of Adult Immunology and Allergy, Department of Chest Disease, Faculty of Medicine, Pendik Training and Research Hospital, Marmara University, Istanbul, Turkey.
Ferah GenelDivision of Immunology and Allergy, Department of Pediatrics, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
Esin Figen DoğuDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ankara University, Ankara, Turkey.
Elif Karakoc-AydinerDivision of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey.
Deniz CagdasDivision of Immunology and Allergy, Department of Pediatrics, Ihsan Dogramacı Children's Hospital, Hacettepe University, Ankara, Turkey.
Guzide AksuDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
Ayca KiykimDivision of Immunology and Allergy, Department of Pediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Sara Sebnem KilicDivision of Immunology and Rheumatology, Department of Pediatrics, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Sevgi KeleşDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Kamile Aydan IkinciogullariDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ankara University, Ankara, Turkey.
İsmail ReisliDivision of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Funding

This study was supported by Selcuk University Scientific Research Projects Coordinatorship (24401102). 24401102
6 · The paper itself

Abstract

Bruton's tyrosine kinase (BTK) is expressed by innate immune cells, and it has been suggested that a lack of BTK may affect monocytes, impacting infection susceptibility and inflammatory response in patients with X-linked agammaglobulinemia (XLA). This study aimed to explore the role of monocyte subsets and monocyte human leucocyte antigen DR (mHLA-DR) expression in patients with XLA. Fifty-nine patients diagnosed with XLA and 37 age-matched healthy subjects were enrolled, and their demographic and clinical features were recorded. Three monocyte subsets were identified-classical (CL) (CD14

Indexed as

AgammaglobulinemiaGenetic Diseases, X-LinkedHLA-DR AntigensMonocytesAdolescentAdultAgammaglobulinaemia Tyrosine KinaseCell PlasticityChildChild, PreschoolFemaleHumansMaleYoung AdultAgammaglobulinaemia Tyrosine KinaseHLA-DR AntigensBruton’s tyrosine kinaseMonocyte HLA-DRMonocyte plasticityX-linked agammaglobulinemia

Identifiers

PMID40970998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.