Evidence map›Paper›PMID 40970989›Full record

ArticleClinical oral investigations2025

Resin infiltration and in-office dental bleaching on different substrates: hydrogen peroxide penetration, color change, and enamel morphology- an in vitro study.

Taynara S Carneiro, Bruno Baracco, Michel Wendlinger, Michael Willian Favoreto, Gabriel Cochinski, Gabrielle Centenaro, Laura Ceballos, Alessandro D Loguercio

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. In Vitro Effects of Combining Resin Infiltration and At-Home Bleaching on Hydrogen Peroxide Penetration, Color Change and Enamel Morphology.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Taynara S CarneiroDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.ORCID http://orcid.org/0000-0001-5796-014X
Bruno BaraccoHealth Sciences Faculty, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain.ORCID http://orcid.org/0000-0003-4398-5957
Michel WendlingerDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.ORCID http://orcid.org/0000-0002-5282-500X
Michael Willian FavoretoHealth Sciences Faculty, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain.ORCID http://orcid.org/0000-0002-0800-7915
Gabriel CochinskiDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.ORCID http://orcid.org/0000-0003-2375-6639
Gabrielle CentenaroDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.ORCID http://orcid.org/0000-0002-6844-202X
Laura CeballosHealth Sciences Faculty, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain.ORCID http://orcid.org/0000-0002-6024-9559
Alessandro D LoguercioDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil. aloguercio@hotmail.com.ORCID http://orcid.org/0000-0001-9880-4856

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304444/2025-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

objectivesTo evaluate the penetration of hydrogen peroxide into the pulp chamber, color change, and enamel morphology of human teeth with different substrates (sound and white spot), subjected to the application of a resin infiltration (RI) and in-office bleaching at different time intervals (immediately and 7 days after RI application). MATERIALS AND

methodsFifty-four sound human premolars were randomly distributed into six groups (n = 9), all subdivided according to substrate (sound and white spot): bleaching with 35% hydrogen peroxide only (HP); RI followed by immediate bleaching (RI/HPi); and RI followed by bleaching after 7 days (RI/HP7d). The concentration of hydrogen peroxide (µg/mL) was measured by UV-Vis spectrophotometry, color change was evaluated using a digital spectrophotometer (ΔE

resultsIn the groups without RI (HP), teeth with white spot lesions showed approximately 40% greater hydrogen peroxide penetration than sound teeth (p = 0.15). RI significantly reduced this penetration, regardless of the substrate or bleaching time (p > 0.02). According to WI

conclusionsThe application of RI prior to in-office bleaching significantly reduced hydrogen peroxide penetration into the pulp chamber without compromising bleaching efficacy. In teeth with white spot lesions, it led to a final shade comparable to that of sound teeth and resulted in a more uniform enamel morphology. CLINICAL RELEVANCE: Resin infiltration is an effective, minimally invasive approach for treating white spot lesions, improving bleaching outcomes and limiting hydrogen peroxide penetration.

Indexed as

Dental EnamelHydrogen PeroxideResins, SyntheticTooth BleachingTooth Bleaching AgentsBicuspidColorHumansIn Vitro TechniquesMicroscopy, Electron, ScanningSpectrophotometrySpectrophotometry, UltravioletSurface PropertiesHydrogen PeroxideResins, SyntheticTooth Bleaching AgentsColor changeDental bleachingDental enamel permeabilityHydrogen peroxideWhite spot lesion

Identifiers

PMID40970989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.