ArticleEuropean archives of psychiatry and clinical neuroscience2026
Early life stress modulates social behavior via oxytocin and arginine vasopressin in males.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Social behaviors are essential for both reproduction and survival. Human and animals exhibit distinct patterns of social interaction following trauma experienced during puberty, which are shaped by the complex interplay between environmental and biological factors. Although neuropeptides and early life stress (ELS) influence social behavior, it remains unclear whether the regulation of neuropeptides in response to ELS further modulates social behavior. Two sex neuropeptides, oxytocin (OT) and arginine vasopressin (AVP), exert profound effects on social behaviors. Therefore, we investigate the involvement of OT and AVP in modulating the alterations in social behavior resulting from ELS. The 89 adult men participants were divided into heterosexual (n=32) and gay/bisexual (n=57) groups. Mental health and the serum levels of OT and AVP were evaluated. Our clinical samples reveal significant variations in ELS exposure across sexual orientation groups, which correlate with neuroendocrine alterations, including altered OT and AVP levels. Animal study further substantiates the critical role of OT and AVP in mediating these changes, highlighting their involvement in shaping social behavior. These findings uncover potential underlying mechanisms through which the OT and AVP systems contribute to stress-induced alterations in social behavior.
Indexed as
Identifiers
40970948What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.