Evidence map›Paper›PMID 40970923›Full record

ArticleAnnals of hematology2025

Impact of inflammatory cytokine polymorphisms on the progression of myelodysplastic syndromes.

Nanami Gotoh, Tsatsralgerel Munkh-Erdene, Ai Hayashi, Tetsuhiro Kasamatsu, Miri Kitamura, Asumi Kojima, Takafumi Okawa, Tsukasa Oda, Eiji Miyauchi, Nobuo Sasaki and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nanami GotohDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan.
Tsatsralgerel Munkh-ErdeneDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan.
Ai HayashiDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan.
Tetsuhiro KasamatsuFaculty of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan.
Miri KitamuraDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan.
Asumi KojimaDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan.
Takafumi OkawaDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan.
Tsukasa OdaLaboratory of Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Eiji MiyauchiLaboratory of Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Nobuo SasakiLaboratory of Mucosal Ecosystem Design, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Ikuko MatsumuraDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Akira MatsumotoDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Hisashi TakeiDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Nobuhiko KobayashiDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Yuri MiyazawaDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Yoshiyuki OgawaDivision of Blood Transfusion Service, Gunma University Hospital, Maebashi, Gunma, Japan.
Hiroshi HandaDepartment of Hematology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Takayuki SaitohDepartment of Laboratory Science, Graduate School of Health Sciences, Gunma University, Maebashi, 371-8514, Gunma, Japan. tsaitoh@gunma-u.ac.jp.

Funding

Japan Science and Technology Agency JPMJPF2301
6 · The paper itself

Abstract

Chronic inflammation is increasingly recognized as a key contributor to tumorigenesis, promoting genomic instability, immune evasion, and malignant transformation. Inflammatory cytokines are particularly involved in the pathogenesis and progression of myelodysplastic syndromes (MDS). This study examined the impact of three cytokine polymorphisms-IFNG + 874 A/T, TNFA - 857 C/T, and IL1B -31 C/T-on MDS susceptibility and clinical characteristics. A total of 105 patients with MDS and 117 healthy Japanese controls were analyzed. High-expression TNFA - 857 C/T was significantly associated with adverse risk categories by the revised International Prognostic Scoring System (high or very high: non-CC vs. CC = 36.4% vs. 7.2%, p < 0.001) and an increased likelihood of transformation to leukemia (non-CC vs. CC = 30.3% vs. 11.6%, p = 0.02). Similarly, IFNG + 874 A/T correlated with a higher risk of leukemic progression (non-AA vs. AA = 33.3% vs. 14.3%, p = 0.04). Moreover, high-expression genotypes of TNFA and IL1B were linked to increased chromosomal abnormalities. In conclusion, our results indicate that high-expression cytokine polymorphisms may contribute to more aggressive forms of MDS. Our findings reveal that the TNFA-857 C/T polymorphism is strongly associated with MDS severity and progression, suggesting its potential as a prognostic biomarker.

Indexed as

CytokinesInterferon-gammaInterleukin-1betaMyelodysplastic SyndromesPolymorphism, Single NucleotideTumor Necrosis Factor-alphaAdultAgedAged, 80 and overDisease ProgressionFemaleHumansMaleMiddle AgedCytokinesIFNG protein, humanIL1B protein, humanInterferon-gammaInterleukin-1betaTumor Necrosis Factor-alphaAcute myeloid leukemiaCytokineInflammationMyelodysplastic syndromesPolymorphism

Identifiers

PMID40970923
PMCPMC12619715

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.