Evidence map›Paper›PMID 40970844›Full record

ArticleFuture medicinal chemistry2025

Anti-alkaline phosphatases (ALP) potentials of potent 4-aminobenzenesulfonamide derivatives against

Saqib Khan, Muhammad Yaqoob, Muhammad H H B Asad, Rafia Falak, Zaman Ashraf, Abdul Mannan, Syed M Bukhari, Fiaz Alam, Umer Rashid

Abstract read
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Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saqib KhanDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Muhammad YaqoobDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Muhammad H H B AsadDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Rafia FalakDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Zaman AshrafDepartment of Chemistry, Rawalpindi Women University, Rawalpindi, Pakistan.
Abdul MannanDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Syed M BukhariDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Fiaz AlamDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim

methodsTargeted derivatives were synthesized and characterized via FTIR,

resultsAmong all the synthetic compounds, (SB-5) showed remarkably potent inhibitory activity against the targeted enzyme (94%, IC

conclusionThe present study confirms the effectiveness of 4-aminobenzenesulfonamide-based derivative (SB-5) as a promising inhibitor of ALP and as a lead candidate for future drug development.

Indexed as

Alkaline PhosphataseElapid VenomsEnzyme InhibitorsSulfonamidesAnimalsMolecular Docking SimulationMolecular StructureNajaStructure-Activity RelationshipAlkaline PhosphataseElapid VenomsEnzyme InhibitorsSulfonamides4-aminobenzenesulfonamide derivativesALPdocking studieskinetic studiesN. oxiana

Identifiers

PMID40970844
PMCPMC12536783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.