Evidence map›Paper›PMID 40970815›Full record

ArticleBiotechnology journal2025

Inline Protein Concentration by Vibratory Single Pass Tangential Flow Filtration.

Km Prottoy Shariar Piash, Ziqiao Wang, Claire MacElroy, Andrew L Zydney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Km Prottoy Shariar PiashDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Ziqiao WangDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Claire MacElroyDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Andrew L ZydneyDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1865-9156

Funding

National Science Foundation
6 · The paper itself

Abstract

Single Pass Tangential Flow Filtration (SPTFF) is increasingly used for inline concentration and final formulation in intensified/continuous processes for monoclonal antibody products. However, these modules typically operate at low feed flux, requiring significant membrane area and often complex internal staging to achieve the desired concentration factor. In this study, a vibration-assisted SPTFF system was used for inline concentration of soluble protein. The maximum sustainable flux and concentration factor were evaluated under vibratory and non-vibratory conditions using flux-stepping experiments. SPTFF performed under vibration was able to achieve single pass concentration factors of 20× at a feed flux of 17.2 L/m

Indexed as

Antibodies, MonoclonalFiltrationProteinsVibrationAntibodies, MonoclonalProteinscontinuous processingdynamic filtrationmonoclonal antibodySPTFFultrafiltration

Identifiers

PMID40970815
PMCPMC12447857

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.