Evidence map›Paper›PMID 40970712›Full record

ArticleJournal of clinical microbiology2025

Evaluation of expert rules for carbapenemase class identification in

Michaela J Eickhoff, Abigail P Brown, Carol E Muenks, Megan L Porter, Murad Ali, Iftikhar Uddin, Tahir Hussain, Melanie L Yarbrough, Rebekah E Dumm

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michaela J EickhoffDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-2376-9237
Abigail P BrownDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Carol E MuenksDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-4294-8134
Megan L PorterDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Murad AliMardan Medical Complex, Mardan, Pakistan.
Iftikhar UddinMardan Medical Complex, Mardan, Pakistan.
Tahir HussainDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Melanie L YarbroughDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-2166-7552
Rebekah E DummDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-3139-3153

Funding

bioMerieux Investigator Initiated StudyCDC HHS 75D301-21-C-11970
6 · The paper itself

Abstract

Prompt identification of enzyme class in carbapenemase-producing carbapenem-resistant IMPORTANCE: Carbapenem-resistant bacteria are a major public health concern due to their ability to spread in healthcare settings and cause infections that are difficult to treat with first-line antibiotics. Identification of the enzyme classes responsible for carbapenem resistance plays a crucial role in ensuring that patients receive effective treatments and controlling the spread of these bacteria. In this study, we evaluated the performance of a new approach to identify carbapenemase enzymes without additional hands-on testing. The method is designed for use with the VITEK2 automated susceptibility testing platform to recognize patterns of resistance to antibiotics and make predictions about the possible resistance mechanisms.

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenem-Resistant EnterobacteriaceaeEnterobacteriaceaeEnterobacteriaceae InfectionsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsSensitivity and SpecificityAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasescarbapenemaseantimicrobial susceptibility testingautomated ASTbacteriologyMDRO

Identifiers

PMID40970712
PMCPMC12506011

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.