ArticleJournal of the American Heart Association2025
Left Ventricular Mass-to-Strain Ratio to Predict Change in Left Ventricular Hypertrophy and Prognosis in Hypertensive Heart Disease.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Machine-learning-derived phenotypes of hypertensive patients using multidimensional clinical and echocardiographic data including strain imaging.European heart journal. Digital health · 2026Article
- The correlation between the systemic inflammation response index and 6-month readmission risk in patients with hypertensive heart disease-related heart failure and its predictive model.Frontiers in medicine · 2026Article
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6 authors.
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Abstract
backgroundA typical hypertensive heart disease phenotype is the left ventricular hypertrophy (LVH) and dysfunction, measurable via LV mass and global longitudinal strain. We aimed to evaluate the LV mass-to-strain ratio (LV-MSR) as a marker of the clinical course in patients with hypertensive heart disease.
methodsWe retrospectively analyzed consecutive patients who underwent echocardiography at the time of hypertension diagnosis and at 6- to 18-month intervals in tertiary centers from 2006 to 2021. Associations of LV-MSR with LVH changes and clinical outcomes (cardiovascular death and heart failure hospitalization occurring after the second echocardiogram) were assessed using time-dependent receiver-operating characteristic analysis and multivariable Cox regression.
resultsAmong 1600 patients (mean age 65.1 years; 61.1% male), 23.4% had concentric LVH, and 21.5% had eccentric LVH at baseline. The median interval between echocardiograms was 10.2 months (interquartile range, 6.8-13.4). LV-MSR showed the highest discriminatory value for LVH changes (area under the curve, 0.726 [95% CI, 0.685-0.760]), outperforming LV mass index (area under the curve, 0.690 [95% CI 0.648-0.728];
conclusionsLV-MSR independently predicts LVH changes and clinical outcomes in hypertensive heart disease, serving as a superior prognostic marker compared with LV mass index or LV-global longitudinal strain alone.
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