ReviewComprehensive reviews in food science and food safety2025
Update on Opium Alkaloids in Food: Exploring Their Occurrence, Effect of Culinary Processing and Advances in Analytical Methodologies.
Review in Comprehensive reviews in food science and food safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Update on Opium Alkaloids in Food: Exploring Their Occurrence, Effect of Culinary Processing and Advances in Analytical Methodologies.Comprehensive reviews in food science and food safety · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Following the implementation of the new European legislation on opium alkaloids (OAs) in food in 2023, scientific research has focused on developing analytical methodologies to determine the presence of these compounds in different foods. However, health authorities continue to suggest further studies to evaluate the occurrence of main OAs and the impact of culinary processing. Concerns remain regarding the potential health risks associated with consuming foods containing OAs. This review provides an updated overview of OAs on food, addressing their occurrence, toxicity, and the risks and benefits associated with poppy seed consumption. It compiles data from recent studies and official reports, including notifications from the Rapid Alert System for Food and Feed (RASFF). Additionally, the influence of culinary processing on OAs concentration is analyzed, highlighting the main findings and research gaps. The review also discusses advancements in analytical methodologies, with emphasis on improvements in green sample preparation to purify extracts and validation of methodologies to improve detection reliability. Elevated concentrations of OAs above legislated limits have been reported. However, various culinary processing methods allow for significant reduction of these levels. Proper control of the initial concentration, together with appropriate processing practices, can mitigate the risks associated with ingestion of contaminated foods. Despite methodological advances in detection, further refinement of analytical methods for different food matrices is needed. Future research should focus on the optimization of these methods for the determination of all OAs, besides morphine and codeine, as well as on the effects of processing and the possible formation of degradation compounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.