ArticleJournal of the American Heart Association2025
Association of Ezetimibe and Statin Combinations With Recurrent Ischemic Stroke: A Nationwide Study With Dual Design.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Ezetimibe alone for over 75 years old as a primary prevention to decrease cardiovascular events.Annals of medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStatin is recommended for patients with ischemic stroke (IS) to lower low-density lipoprotein cholesterol. Although combining statin with ezetimibe further reduced low-density lipoprotein cholesterol, its impact on IS recurrence has varied by statin type.
methodsWe used 2 study designs-a retrospective cohort and a case-control study-using the Korean Health Insurance Review and Assessment database. Patients hospitalized for IS between July 2017 and July 2021 who were treated with atorvastatin or rosuvastatin were included. The cohort study compared recurrent IS risk between ezetimibe users and nonusers, using 1:1 propensity score matching for baseline characteristics. The case-control study assessed ezetimibe use between recurrent cases with IS and age-, sex-, index year-matched controls. Cox proportional hazards and logistic regression models were used to calculate hazard ratios (HRs) and adjusted HRs (aHRs) for the cohort study, as well as odds ratios (ORs) and adjusted ORs (aORs) for the case-control study. We conducted several sensitivity analyses.
resultsAmong 26 937 patients with IS (16 215 atorvastatin, 10 722 rosuvastatin), the cohort study showed ezetimibe combined with atorvastatin significantly reduced recurrent IS incidence (aHR, 0.73 [95% CI, 0.55-0.98],
conclusionsEzetimibe combined with atorvastatin was associated with lower recurrent IS rates compared with atorvastatin alone, whereas its addition to rosuvastatin showed no significant association.
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