Molecular Basis of Calcium-Induced Acidic Shift in Antimicrobial Zinc Sequestration by S100A12.

Mahil Kothalawala, Shaan Shirazi, Qian Wang, Ahava Collado, Angelo Bongiorno, Rupal Gupta

Abstract read

In one paragraph

Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahil KothalawalaDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York 10314, United States.

Shaan ShiraziDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York 10314, United States.

Qian WangDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York 10314, United States.

Ahava ColladoDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York 10314, United States.

Angelo BongiornoDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York 10314, United States.ORCID 0000-0001-5661-9265

Rupal GuptaDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York 10314, United States.ORCID 0000-0001-8637-6129

Funding

Interdependence of Antimicrobial and Pro-inflammatory Activities Mediated byS100A12 in the Innate Immune ResponseR15GM131338 · NIGMS · COLLEGE OF STATEN ISLAND · PI GUPTA, RUPAL · 2019 to 2022

$936k

NIGMS NIH HHS R15 GM131338

6 · The paper itself

Abstract

Antimicrobial protein S100A12 sequesters Zn(II) via a His

Indexed as

CalciumS100A12 ProteinZincHumansHydrogen-Ion ConcentrationMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein BindingCalciumS100A12 ProteinS100A12 protein, humanZinc

Identifiers

PMID40970396

DOI10.1021/acs.jpcb.5c04464

PMCPMC12498495

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.