Evidence map›Paper›PMID 40970301›Full record

ArticleChembiochem : a European journal of chemical biology2025

Oleanolic Acid Amide Derivatives as 20s Proteasome Stimulators.

Jaida M Osman, Duno S Dantis, Hanna King, Darci Jones Trader

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jaida M OsmanDepartment of Chemistry, University of California, Irvine, California, 92617, USA.
Duno S DantisDepartment of Chemistry, University of California, Irvine, California, 92617, USA.
Hanna KingDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, 47907, USA.
Darci Jones TraderDepartment of Chemistry, University of California, Irvine, California, 92617, USA.ORCID https://orcid.org/0000-0002-0607-1243

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Regulation of CD1d by the Invariant ChainR01AI050847 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2002 to 2006
$1.5M
NCI NIH HHS P30 CA062203NIAID NIH HHS R01 AI050847NIH-NIAID 1R01AI50847UCI School of Pharmacy; UCI Chao Family Comprehensive Cancer Center P30CA062203
6 · The paper itself

Abstract

Oleanolic acid (OA), a pentacyclic triterpenoid natural product, is previously identified as a proteasome stimulator using purified proteasome. Structure-activity relationship studies are carried out on OA at the C

Indexed as

AmidesOleanolic AcidProteasome Endopeptidase ComplexHumansMolecular StructureStructure-Activity RelationshipAmidesOleanolic AcidProteasome Endopeptidase Complexoleanolic acidsprobesproteasomessteroidsstimulators

Identifiers

PMID40970301
PMCPMC12687569

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.