ArticleTherapeutic advances in medical oncology2025
Association between pretreatment emotional distress and survival outcomes in patients with advanced non-small-cell lung cancer: an individual patient data meta-analysis of 4632 patients in seven trials.
Article in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Emotional distress and clinical response to neoadjuvant chemoimmunotherapy in resectable non-small-cell lung cancer: a protocol for the prospective observational NeoFUSE-Lung cohort study.Translational lung cancer research · 2026Article
- Psychological distress as a putative host-state determinant of cancer immunotherapy response.Frontiers in immunology · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Emotional distress (ED) is associated with worse survival outcomes in patients with melanoma and non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). However, several preclinical studies suggest the association between stress and cancer treatment extends beyond ICIs alone. Objectives: To systematically evaluate the relationship between ED and NSCLC patient prognosis. Design: This study is an individual patient data (IPD) meta-analysis. Data sources and methods: Relevant studies were identified from the PubMed, Web of Science, The Cochrane Library, Embase, and Vivli databases to obtain IPD up to February 2025. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the association between ED and patient prognosis. Subgroup analysis was conducted based on patient treatment methods. Results: Kaplan-Meier analysis shows that compared with patients without ED, patients with ED had worse survival outcomes, regardless of ICIs or chemotherapy (CT) (HR of overall survival (OS), 1.21 (1.11-1.33), p = 0.01; hazard ratio of progression-free survival (PFS), 1.19 (1.07-1.31), p = 0.01). IPD meta-analysis also supported results above (HR of OS, 1.18, 95% CI, 1.07-1.30; HR of PFS, 1.15, 95% CI, 1.03-1.28). Conclusion: Our research suggests that ED is only a prognostic biomarker in NSCLC, rather than a predictive biomarker for ICIs.
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