ArticleiScience2025
Propofol differentially modulates the consolidation of schema-related and -unrelated memory.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Semantic relatedness of newly learned information to previous knowledge (i.e., a schema) leads to facilitated encoding and rapid integration into neocortical memory networks. The precise dynamics of this process in humans is still poorly understood. Here, we used the GABA-A-ergic anesthetic propofol to transiently suppress neural activity shortly after the encoding of schema-related and -unrelated verbal information in human patients. We found a significant difference in memory of schema-related and -unrelated words in patients that was absent in controls. This effect was driven by a benefit for schema-related words, thus suggesting that propofol administration facilitated the consolidation of previously encoded schema-related information. Our results suggest that schema-relatedness of newly learned information significantly influences the involvement of brain networks shortly after encoding. They further support the hypothesis of a competitive interaction between networks supporting schema-related and -unrelated memoranda during early memory consolidation.
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