Evidence map›Paper›PMID 40970130›Full record

ArticlebioRxiv : the preprint server for biology2025

A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc-haploinsufficiency in the absence of p53.

Xiaozhong Bao, Zied Abdullaev, Subhendu K Das, Valerie Zgonc, Kris Ylaya, Stefania Pittaluga, Stephen M Hewitt, John M Sedivy, Svetlana J Pack, Susan Mackem and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaozhong BaoCancer and Developmental Biology Laboratory, CCR, NCI, Frederick, MD.
Zied AbdullaevLaboratory of Pathology, CCR, NCI, Bethesda, MD.ORCID 0000-0001-6345-2088
Subhendu K DasLaboratory of Pathology, CCR, NCI, Bethesda, MD.
Valerie ZgoncLaboratory of Pathology, CCR, NCI, Bethesda, MD.
Kris YlayaLaboratory of Pathology, CCR, NCI, Bethesda, MD.
Stefania PittalugaLaboratory of Pathology, CCR, NCI, Bethesda, MD.
Stephen M HewittLaboratory of Pathology, CCR, NCI, Bethesda, MD.
John M SedivyDept. of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence RI.
Svetlana J PackLaboratory of Pathology, CCR, NCI, Bethesda, MD.
Susan MackemCancer and Developmental Biology Laboratory, CCR, NCI, Frederick, MD.
David LevensLaboratory of Pathology, CCR, NCI, Bethesda, MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

hemangiosarcomamouse tumor modelsMyc haplo-insufficiencyMyc tumorigenesis thresholdp53 knockout neoplasiathymic lymphoma

Identifiers

PMID40970130
PMCPMC12443044

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.