Evidence map›Paper›PMID 40970114›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Distinct gut microbiome shifts in the NICU influence later atopic dermatitis development.

Emily S Robbins, Kathryn E McCauley, Rachel Strength, Sivaranjani Namasivyam, Angelina G Angelova, Ruhika Prasad, Anal Patel, Varsha Deopujari, Andrew S Burns, Shreni Mistry and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Emily S RobbinsClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Kathryn E McCauleyBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Rachel StrengthClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Sivaranjani NamasivyamClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Angelina G AngelovaBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Ruhika PrasadClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Anal PatelClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Varsha DeopujariInova Children's Hospital, Inova Health System, Falls Church, VA.
Andrew S BurnsNIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Shreni MistryNIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Rajiv BavejaFairfax Neonatal Associates, Inova L.J. Murphy Children's Hospital, Inova Health System, Fairfax, VA.
Robin L BakerFairfax Neonatal Associates, Inova L.J. Murphy Children's Hospital, Inova Health System, Fairfax, VA.
Pamela A Frischmeyer-GuerrerioFood Allergy research Section, Laboratory of Allergic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Shira LevyClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
Suchitra K HouriganClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While it has previously been shown that early life gut microbiome imbalance is associated with the later development of atopic dermatitis (AD) in full term infants, to our knowledge no similar studies have been conducted in infants admitted to the Neonatal Intensive Care Unit (NICU). This is an important research gap to address because a) infants in the NICU are at an increased risk for gut microbiome dysbiosis due to several clinical and environmental factors including frequent antimicrobial exposure; and b) their risk of developing AD may be different from full term infants. We demonstrate gut microbiome dysbiosis and clinical factors impacting the microbiome associated with later development of AD that are unique to infants in the NICU. These may represent early predictors of AD development and potential therapeutic targets to mitigate future disease.

Indexed as

atopydelivery modeEczemamicrobiotaneonatepreterm

Identifiers

PMID40970114
PMCPMC12443057

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.